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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
A comparative cytotoxicity study of isomeric alkylphthalates to metabolically variant bacteria
Journal of Hazardous Materials, Volume 182, No. 1-3, Year 2010
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Description
This work investigated the toxicity of two isomeric alkylphthalates, i.e., di-n-octyl phthalate (DOP) and di-2-ethylhexyl phthalate (DEHP) to two model bacteria, Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis), which have been previously used to study the toxicity of environmental pollutants. Microcalorimetry was used as the key analytical tool alongside scanning electron microscopy (SEM) and traditional microbiology techniques. The thermokinetic parameters from microcalorimetry showed that the phthalates had a biphasic effect on the metabolic activities of the bacteria; serving as energy sources for the bacteria thereby stimulating their growth at low dosages (≤150. μg/mL), but displaying inhibitory effects at higher dosages (≥300. μg/mL), indicated by a sharp decrease in growth rate constants at 450. μg/mL. The SEM revealed that the bacterial cells were morphological deformed, with shrunk cells and elongated strands at 600. μg/mL of both phthalates. The elongated strands inferred that the phthalates inhibited the reproductive processes of the bacteria by possibly impeding some stages of cell division. The half inhibitory concentrations of the phthalates showed that DEHP was more toxic than DOP. Additionally, E. coli, a facultative anaerobe, was more susceptible to the toxic effects of phthalates than B. subtilis, an obligate aerobe capable of forming endospores crucial for tolerating extreme environmental conditions. © 2010 Elsevier B.V.
Authors & Co-Authors
Sandy, Edward H.
China, Wuhan
Sino-hungary Joint Environmental Science and Health Laboratory
Sierra Leone, Freetown
Fourah Bay College
Yao, Jun
China, Wuhan
Sino-hungary Joint Environmental Science and Health Laboratory
Zheng, Shixue
China, Wuhan
Huazhong Agricultural University
Gogra, Alhaji B.
China, Wuhan
Sino-hungary Joint Environmental Science and Health Laboratory
Chen, Huilun
China, Wuhan
Sino-hungary Joint Environmental Science and Health Laboratory
Zheng, Hui
China, Wuhan
Huazhong Agricultural University
Yormah, Thomas B.R.
Sierra Leone, Freetown
Fourah Bay College
Zhang, Xin
United States, New Haven
Yale University
Zaray, Gyula
Hungary, Budapest
Eötvös Loránd Tudományegyetem
Ceccanti, Brunello
Italy, Rome
Consiglio Nazionale Delle Ricerche
Choi, Martin M.F.
Hong Kong, Hong Kong
Hong Kong Baptist University
Statistics
Citations: 11
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.jhazmat.2010.06.079
ISSN:
03043894
Research Areas
Environmental
Noncommunicable Diseases
Sexual And Reproductive Health