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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology
Acta Neurologica Scandinavica, Volume 138, No. 6, Year 2018
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Description
Objectives: Neuropsychological sequelae are a feature of benign epilepsy with centrotemporal spikes (BECTS) in children. A correlation between the frequency of interictal EEG discharges and the cognitive as well as behavioral profile of the patients has been suspected but not proven. Materials and methods: Children with BECTS that had not yet been treated were included into a randomized controlled trial. In the initial visit, EEGs were recorded. The frequency of interictal discharges was quantified. Correlations between the discharge frequency and the performance in a neuropsychological test battery were examined. Results: The cognitive test results were within or slightly above normal range (Culture-free intelligence test: 99.4%-confidence interval [CI]: [50.3, 59.9], test standardized to a population mean of 50). Parent-reported behavioral abnormalities were statistically significantly increased (CBCL total score CI: [51.9, 61.9], population mean as above). Correlations between the frequency of interictal epileptic discharges and the test results could not be identified (lowest encountered P-value: 0.034, not significant after correction for multiple testing). Conclusion: The data do not support the hypothesis that the frequency of the interictal EEG discharges influences the neurocognitive performance or behavioral parameters of children with BECTS. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Authors & Co-Authors
Tacke, Moritz
Germany, Munich
Ludwig-maximilians-universität München
Vill, Katharina
Germany, Munich
Ludwig-maximilians-universität München
Bast, Thomas
Germany, Freiburg Im Breisgau
Universität Freiburg
Borggraefe, Ingo
Germany, Munich
Ludwig-maximilians-universität München
Baumeister, Friedrich A.M.
Unknown Affiliation
Bode, Harald
Unknown Affiliation
Wagner, Ryan G.
Unknown Affiliation
Brandl, Ulrich
Unknown Affiliation
Brockmann, Knut
Unknown Affiliation
Klepper, Jörg
Unknown Affiliation
Kluger, Gerhard Josef
Unknown Affiliation
Korinthenberg, Rudolf
Unknown Affiliation
Kurlemann, Gerhard
Unknown Affiliation
Rating, Dietz
Unknown Affiliation
Schara, Ulrike
Unknown Affiliation
Stephani, Ulrich
Unknown Affiliation
Mühle, Hiltrud
Unknown Affiliation
Waltz, Stephan
Unknown Affiliation
Wolff, Markus
Unknown Affiliation
Polster, Tilman
Unknown Affiliation
Statistics
Citations: 4
Authors: 20
Affiliations: 4
Identifiers
Doi:
10.1111/ane.13015
ISSN:
00016314
Research Areas
Cancer
Maternal And Child Health
Mental Health
Study Design
Cross Sectional Study
Study Approach
Quantitative