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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Persistent SARS-CoV-2 RNA Shedding without Evidence of Infectiousness: A Cohort Study of Individuals with COVID-19
Journal of Infectious Diseases, Volume 224, No. 8, Year 2021
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Description
Background: To better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding and infectivity, we estimated SARS-CoV-2 RNA shedding duration, described participant characteristics associated with the first negative rRT-PCR test (resolution), and determined if replication-competent viruses was recoverable ≥10 days after symptom onset. Methods: We collected serial nasopharyngeal specimens from 109 individuals with rRT-PCR-confirmed COVID-19 in Utah and Wisconsin. We calculated viral RNA shedding resolution probability using the Kaplan-Meier estimator and evaluated characteristics associated with shedding resolution using Cox proportional hazards regression. We attempted viral culture for 35 rRT-PCR-positive nasopharyngeal specimens collected ≥10 days after symptom onset. Results: The likelihood of viral RNA shedding resolution at 10 days after symptom onset was approximately 3%. Time to shedding resolution was shorter among participants aged <18 years (adjusted hazards ratio [aHR], 3.01; 95% confidence interval [CI], 1.6-5.6) and longer among those aged ≥50 years (aHR, 0.50; 95% CI,. 3-.9) compared to participants aged 18-49 years. No replication-competent viruses were recovered. Conclusions: Although most patients were positive for SARS-CoV-2 for ≥10 days after symptom onset, our findings suggest that individuals with mild to moderate COVID-19 are unlikely to be infectious ≥10 days after symptom onset. © 2021 Published by Oxford University Press for the Infectious Diseases Society of America 2021.
Authors & Co-Authors
Owusu, Daniel
United States, Atlanta
Centers for Disease Control and Prevention
Whitaker, Brett L.
United States, Atlanta
Centers for Disease Control and Prevention
Dietrich, Elizabeth A.
United States, Atlanta
Centers for Disease Control and Prevention
Hall, Aron J.
United States, Atlanta
Centers for Disease Control and Prevention
Thornburg, Natalie J.
United States, Atlanta
Centers for Disease Control and Prevention
Pray, Ian W.
United States, Atlanta
Centers for Disease Control and Prevention
United States, Madison
Wisconsin Department of Health Services
Bhattacharyya, Sanjib
United States, Milwaukee
City of Milwaukee Health Department
Dunn, Angela C.
United States, Salt Lake City
Utah Department of Health
Tate, Jacqueline E.
United States, Atlanta
Centers for Disease Control and Prevention
Kirking, Hannah L.
United States, Atlanta
Centers for Disease Control and Prevention
Matanock, Almea M.
United States, Atlanta
Centers for Disease Control and Prevention
Gharpure, Radhika V.
Unknown Affiliation
Njuguna, Henry N.
Unknown Affiliation
Dawson, Patrick
Unknown Affiliation
Salvatore, Phillip P.
Unknown Affiliation
Marcenac, Perrine
Unknown Affiliation
Fajans, Mark A.
Unknown Affiliation
Laws, Rebecca L.
Unknown Affiliation
Pevzner, Eric S.
Unknown Affiliation
Battey, Katherine A.
Unknown Affiliation
Tran, Cuc H.
Unknown Affiliation
Vuong, Jeni T.
Unknown Affiliation
Gregory, Christopher J.
Unknown Affiliation
Lester, Sandra N.
Unknown Affiliation
Fry, Alicia M.
Unknown Affiliation
Nabity, Scott A.
Unknown Affiliation
Statistics
Citations: 56
Authors: 26
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jiab107
ISSN:
00221899
Research Areas
Covid
Study Design
Cohort Study
Study Approach
Quantitative