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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
Nature Genetics, Volume 42, No. 12, Year 2010
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Description
Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y. pestis isolates for 933 SNPs using Sequenom MassArray SNP typing. We conducted phylogenetic analyses on this sequence variation dataset, assigned isolates to populations based on maximum parsimony and, from these results, made inferences regarding historical transmission routes. Our phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs. All 626 current isolates from the United States reflect one radiation, and 82 isolates from Madagascar represent a second radiation. Subsequent local microevolution of Y. pestis is marked by sequential, geographically specific SNPs. © 2010 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Morelli, Giovanna
Germany, Berlin
Max Planck Institute for Infection Biology
Germany, Berlin
Max Planck Institute for Molecular Genetics
Song, Yajun
China, Beijing
Academy of Military Sciences
Ireland, Cork
University College Cork
Mazzoni, Camila Junqueira
Germany, Berlin
Max Planck Institute for Infection Biology
Ireland, Cork
University College Cork
Germany, Berlin
Berlin Center for Genomics in Biodiversity Research
Eppinger, Mark
United States, Baltimore
University of Maryland School of Medicine
Roumagnac, Philippe
Germany, Berlin
Max Planck Institute for Infection Biology
France, Paris
Cirad
Wagner, David M.
United States, Flagstaff
Northern Arizona University
Feldkamp, Mirjam
Germany, Berlin
Max Planck Institute for Infection Biology
Germany, Berlin
Max Delbruck Center for Molecular Medicine
Kušećek, Barica
Germany, Berlin
Max Planck Institute for Infection Biology
Germany, Berlin
Max Planck Institute for Molecular Genetics
Vogler, Amy J.
United States, Flagstaff
Northern Arizona University
Li, Yanjun
China, Beijing
Academy of Military Sciences
Cui, Yujun
China, Beijing
Academy of Military Sciences
Thomson, Nicholas Robert
United Kingdom, Hinxton
Wellcome Sanger Institute
Jombart, Thibaut
United Kingdom, London
Imperial College Faculty of Medicine
Leblois, Raphaël
France, Paris
Museum National D'histoire Naturelle
Lichtner, Peter K.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Rahalison, Lila
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Petersen, Jeannine M.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Balloux, François
United Kingdom, London
Imperial College Faculty of Medicine
Keim, Paul S.
United States, Flagstaff
Northern Arizona University
United States, Phoenix
Translational Genomics Research Institute
Wirth, Thierry
Germany, Berlin
Max Delbruck Center for Molecular Medicine
Ravel, Jacques
United States, Baltimore
University of Maryland School of Medicine
Yang, Ruifu
China, Beijing
Academy of Military Sciences
Carniel, Élisabeth
France, Paris
Institut Pasteur, Paris
Achtman, Mark
Germany, Berlin
Max Planck Institute for Infection Biology
Ireland, Cork
University College Cork
Statistics
Citations: 463
Authors: 24
Affiliations: 17
Identifiers
Doi:
10.1038/ng.705
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Cancer
Study Locations
Madagascar