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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery
Colorectal Disease, Volume 20, Year 2018
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Description
Introduction: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging. Results: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as ‘fair’ only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively). Conclusion: The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials. Colorectal Disease © 2018 The Association of Coloproctology of Great Britain and Ireland
Authors & Co-Authors
Glasbey, James C.
Unknown Affiliation
Neary, Peter Mark
Unknown Affiliation
Negoi, Ionut
Unknown Affiliation
Kamarajah, Sivesh K.
Unknown Affiliation
Sgro, Alessandro
Unknown Affiliation
Bhangu, Aneel Amir
Unknown Affiliation
Pinkney, Thomas D.
Unknown Affiliation
Frasson, Matteo
Unknown Affiliation
El-Hussuna, Alaa
Unknown Affiliation
Buchs, Nicolas Christian
Unknown Affiliation
Buskens, Christianne Johanna
Unknown Affiliation
Gallo, Gaetano
Unknown Affiliation
Minaya-Bravo, Ana M.
Unknown Affiliation
Dion G. Morton, Dion Gregory M.
Unknown Affiliation
Nepogodiev, Dmitri
Unknown Affiliation
Pata, Francesco
Unknown Affiliation
Sanchez-Guillen, Luís
Unknown Affiliation
Zmora, Oded
Unknown Affiliation
Perry, Rita J.
Unknown Affiliation
Magill, Laura
Unknown Affiliation
Bemelman, Willem Adrianus
Unknown Affiliation
Brown, Steven Ross
Unknown Affiliation
Denost, Quentin D.
Unknown Affiliation
Knowles, Charles H.
Unknown Affiliation
Laurberg, Soren
Unknown Affiliation
Möeslein, Gabriela
Unknown Affiliation
Vaizey, Carolynne J.
Unknown Affiliation
Proud, David M.
Unknown Affiliation
Warwick, Andrea Marie
Unknown Affiliation
Francart, David
Unknown Affiliation
Muysoms, Filip E.
Unknown Affiliation
Wolthuis, Albert M.
Unknown Affiliation
Delibegović, Samir
Unknown Affiliation
Tercioti, Valdir
Unknown Affiliation
Dardanov, Dragomir
Unknown Affiliation
Maslyankov, Svilen
Unknown Affiliation
Lozev, Ilia I.
Unknown Affiliation
Slavchev, M.
Unknown Affiliation
Atanasov, Boyko Tchavdarov
Unknown Affiliation
Belev, Nikolay
Unknown Affiliation
Škrovina, Matěj
Unknown Affiliation
Christensen, Peter Astrup
Unknown Affiliation
Elfeki, Hossam Ayman
Unknown Affiliation
Kristensen, Marianne Højsgaard
Unknown Affiliation
Elgeidie, Ahmed Abdelraouf
Unknown Affiliation
Elhemaly, Mohamed
Unknown Affiliation
El Nakeeb, Ayman M.
Unknown Affiliation
Shalaby, Mostafa
Unknown Affiliation
Emile, Sameh Hany
Unknown Affiliation
Sakr, Ahmad Hammad
Unknown Affiliation
Thabet, Waleed Mohamed
Unknown Affiliation
Awny, Shadi
Unknown Affiliation
Metwally, Islam Hany
Unknown Affiliation
Refky, Basel
Unknown Affiliation
Zuhdy, Mohammad
Unknown Affiliation
Lepistö, Anna H.
Unknown Affiliation
Rautio, Tero T.
Unknown Affiliation
Lehto, Kirsi Maarit
Unknown Affiliation
Gléhen, Olivier J.
Unknown Affiliation
Passot, Guillaume
Unknown Affiliation
Chouillard, Élie K.
Unknown Affiliation
Ayav, Ahmet
Unknown Affiliation
Rullier, Éric
Unknown Affiliation
Lakkis, Zaher
Unknown Affiliation
Schafmayer, Clemens
Unknown Affiliation
Kienle, Peter
Unknown Affiliation
Alexandrou, Andreas P.
Unknown Affiliation
Chouliaras, Christos
Unknown Affiliation
Balalis, Dimitrios
Unknown Affiliation
Korkolis, Dimitrios P.
Unknown Affiliation
Manatakis, Dimitrios K.
Unknown Affiliation
Besznyǎk, István
Unknown Affiliation
Bursics, Attila
Unknown Affiliation
Mehraj, Asif
Unknown Affiliation
Cahill, Ronan A.
Unknown Affiliation
Mulsow, Jürgen J.W.
Unknown Affiliation
Kelly, Michael Eamon
Unknown Affiliation
Ryan, Eanna J.
Unknown Affiliation
Gefen, Rachel
Unknown Affiliation
Raguan, Barak
Unknown Affiliation
Wasserberg, Nir
Unknown Affiliation
Freund, Michael R.
Unknown Affiliation
Tulchinsky, Hagit
Unknown Affiliation
Agresta, Ferdinando
Unknown Affiliation
Tamini, Nicolò
Unknown Affiliation
Gianotti, Luca
Unknown Affiliation
Morino, Mario
Unknown Affiliation
Delrio, Paolo
Unknown Affiliation
Montroni, Isacco
Unknown Affiliation
Spinelli, Antonino
Unknown Affiliation
Sacchi, Matteo M.
Unknown Affiliation
Frontali, A.
Unknown Affiliation
Ceriani, Valerio
Unknown Affiliation
Rosati, Riccardo
Unknown Affiliation
Elmore, Ugo
Unknown Affiliation
Casoni Pattacini, Gianmaria
Unknown Affiliation
Foschi, D. A.
Unknown Affiliation
Di Saverio, S.
Unknown Affiliation
Birindelli, Arianna
Unknown Affiliation
Romano, Giovannni Maria
Unknown Affiliation
Belli, Andrea A.B.
Unknown Affiliation
Bianco, Francesco Maria
Unknown Affiliation
Falato, Armando
Unknown Affiliation
Tugnoli, Gregorio
Unknown Affiliation
Podda, Mauro Guido
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Galleano, R.
Unknown Affiliation
Feroci, Francesco
Unknown Affiliation
Cocorullo, Gianfranco F.
Unknown Affiliation
Licari, Leo
Unknown Affiliation
Sileri, Pierpaolo
Unknown Affiliation
Saraceno, Federica
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Chirletti, Pietro
Unknown Affiliation
Coletta, Diego
Unknown Affiliation
Mingoli, Andrea
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Sacco, Rosario
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Tonini, Valeria
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Sartori, Alberto
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Balducci, Genoveffa
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Bocchetti, Tommaso
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Anania, Gabriele
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Carcoforo, Paolo
Unknown Affiliation
Yamamoto, Takayuki
Unknown Affiliation
Venskutonis, Donatas
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Eismontas, Vitalijus
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Dulskas, Audrius
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Poškus, Tomas
Unknown Affiliation
Zakaria, Andee Dzulkarnaen
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Wong, Michael Pak Kai
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Ahallat, Mohamed
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Hrora, Abdelmalek El Malk
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Majbar, Anass Mohammed
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Westerduin, Emma
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Tanis, Pieter Job
Unknown Affiliation
Smakman, Niels
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Zimmerman, David D.E.
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Stijns, Jasper
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den Boer, Frank C.
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Anwer, Mariyah
Unknown Affiliation
Qureshi, Ahmad Uzair
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Rama, Nuno José Gomes
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Domingos, Hugo
Unknown Affiliation
Cunha, Miguel F.
Unknown Affiliation
Martins, Ruben S.
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Simoes, Joana F.F.
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Scurtu, Radu Razvan
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Calu, Valentin
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Enciu, Octavian
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Mogoanta, Stelian Ştefǎniţǎ
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Beuran, Mircea
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Ciubotaru, Cezar I.
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Copãescu, Cǎtǎlin Andu
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Katorkin Sergei, E.
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Vardanyan, A. V.
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Ngu, James Chi Yong
Unknown Affiliation
Teo, Nan Zun
Unknown Affiliation
Rems, Miran
Unknown Affiliation
Blas, Juan Luis
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Cuadrado-Ayuso, Marta Bailón
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Ruíz-Camps, Isabel
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Gómez-Ruiz, Marcos
Unknown Affiliation
ROS, EMILIO Peña
Unknown Affiliation
Sanchiz-Cárdenas, Elena M.
Unknown Affiliation
Jime´nez-Rodrı´guez, Rosa María
Unknown Affiliation
De la Portilla, Fernando De La
Unknown Affiliation
Millán-Scheiding, Mónica M.
Unknown Affiliation
Flor-Lorente, Blas
Unknown Affiliation
Myrelid, Pär E.
Unknown Affiliation
Buchwald, Pamela L.
Unknown Affiliation
Syk, Ingvar K.
Unknown Affiliation
Adamina, Michel
Unknown Affiliation
Oertli, Daniel
Unknown Affiliation
Hahnloser, Dieter
Unknown Affiliation
Hübner, Martin
Unknown Affiliation
Ris, Frédéric
Unknown Affiliation
Morel, Philippe
Unknown Affiliation
Isik, Arda A.
Unknown Affiliation
Kozak, Osman Samil
Unknown Affiliation
Işık, Özgen
Unknown Affiliation
Çolak, Elif F.
Unknown Affiliation
Fearnhead, Nicola S.
Unknown Affiliation
Zammit, Matthew
Unknown Affiliation
Seretis, Fotios
Unknown Affiliation
Jones, Conor Stephen
Unknown Affiliation
Boland, Michael R.
Unknown Affiliation
Statistics
Citations: 23
Authors: 184
Identifiers
Doi:
10.1111/codi.14361
ISSN:
14628910
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study