Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Management of duodenal adenomatosis in patients with familial adenomatous polyposis
Annales de Chirurgie, Volume 128, No. 9, Year 2003
Notification
URL copied to clipboard!
Description
Aim of the study. - To review our global management of duodenal adenomas in patients with familial adenomatous polyposis and report the results of different therapeutic approaches. To present the outcome and possible sequels of pancreaticoduodenectomy. Patients and methods. - We identified five cases of duodenal adenomas in patients with familial adenomatous polyposis over a period of 10 years (1992-2001), we followed the progression of their Spigelman score. Results of conservative and surgical treatment were collected. Results. - Duodenal adenomas were discovered 5-33 years after the first operation for colonic polyposis. The score of Spigelman was as follows: 2, stage 2; 3, stage 3; 1, stage 4. Endoscopic laser therapy followed by Sulindac prescription was proposed in three cases, with only one success. Duodenopancreatectomy was performed in four patients: once the diagnosis of adenoma was made in one patient, due to Spigelman stage 4 with severe dysplasia, because development of intramucosal carcinoma under surveillance in one patient, and after failure or complication of conservative treatment in two others. Worsening of Spigelman score was observed in two out of four patients submitted to conservative therapy. Correlation between Spigelman score and final examination of the specimen was correct in two cases. There was neither significant morbidity nor long-term nutritional sequel after pancreaticoduodenectomy. Conclusion. - Duodenal adenomas may recur or progress into malignant degeneration under conservative treatment. The pancreaticoduodenectomy is an acceptable solution for stage 4 of Spigelman, especially when severe dysplasia is present. © 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits réservés.
Authors & Co-Authors
Fawal, H.
Lebanon, Beirut
Hôp. Gén. de Makassed
Gambiez, Luc P.
France, Lille
Chu Lille
Raad, A.
Lebanon, Beirut
Hôp. Gén. de Makassed
Pruvot, Franc¸ois Rene´ R.
France, Lille
Chu Lille
Chambon, Jean Pierre M.
France, Lille
Chu Lille
Saudemont, Alain
France, Lille
Chu Lille
Quandallé, Pierre A.
France, Lille
Chu Lille
Statistics
Citations: 7
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/j.anchir.2003.09.011
ISSN:
00033944
Research Areas
Cancer
Health System And Policy