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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis C virus treatment in the real world: Optimising treatment and access to therapies
Gut, Volume 64, No. 11, Year 2015
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Description
Chronic HCV infections represent a major worldwide public health problem and are responsible for a large proportion of liver related deaths, mostly because of HCV-associated hepatocellular carcinoma and cirrhosis. The treatment of HCV has undergone a rapid and spectacular revolution. In the past 5 years, the launch of direct acting antiviral drugs has seen sustained virological response rates reach 90% and above for many patient groups. The new treatments are effective, well tolerated, allow for shorter treatment regimens and offer new opportunities for previously excluded groups. This therapeutic revolution has changed the rules for treatment of HCV, moving the field towards an interferon-free era and raising the prospect of HCV eradication. This manuscript addresses the new challenges regarding treatment optimisation in the real world, improvement of antiviral efficacy in 'hard-to-treat' groups, the management of patients whose direct acting antiviral drug treatment was unsuccessful, and access to diagnosis and treatment in different parts of the world. © 2015, BMJ Publishing Group. All rights reserved.
Authors & Co-Authors
Zoulim, Fabien
France, Villeurbanne
Université Claude Bernard Lyon 1
Liang, Jake Jake
United States, Bethesda
National Institutes of Health Nih
Aghemo, Alessio
Italy, Milan
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
Deuffic-Burban, Sylvie
France, Paris
Inserm
France, Paris
Université Paris Cité
France, Lille
Université de Lille
Dusheiko, Geoffrey M.
United Kingdom, London
University College London
Fried, Michael W.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Pol, Stanislas
France, Paris
Institut Pasteur, Paris
Rockstroh, Jürgen Kurt
Germany, Bonn
Universitätsklinikum Bonn
Terrault, Norah A.
United States, San Francisco
University of California, San Francisco
Wiktor, Stefan Zbyszko
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 116
Authors: 10
Affiliations: 13
Identifiers
Doi:
10.1136/gutjnl-2015-310421
ISSN:
00175749
Research Areas
Cancer
Health System And Policy
Infectious Diseases