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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Malaria in São Tomé and Principe: On the brink of elimination after three years of effective antimalarial measures
American Journal of Tropical Medicine and Hygiene, Volume 80, No. 1, Year 2009
Notification
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Description
In 2005, São Tomé e Príncipe began an initiative aimed at reducing malaria-related mortality to zero. The program included mass coverage with two antivector intervention methods (indoor residual spraying and long-lasting insecticidal nets), artemisinin-based combination therapy, and intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine. At the end of 2007, three years after intensified interventions began, malaria-attributed outpatient consultations, hospitalizations, and deaths decreased by more than 85%, 80%, and 95%, respectively, in all age groups. Mean prevalence of parasitemia and splenomegaly were also significantly reduced to 2.1 % (P < 0.0001) and 0.3% (P < 0.0001) after two rounds of spraying from baseline prevalences of 30.5% and 48.8%, respectively. The dramatic reduction in malaria morbidity and mortality now enable serious consideration of new goals and strategies aimed at completely interrupting malaria transmission on these islands. We report evidence of the program's impact and the feasibility of and potential strategies for eliminating malaria from São Tomé e Príncipe. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Teklehaimanot, Hailay D.
United States, New York
Earth Institute
Ethiopia, Addis Ababa
Center for National Health Development in Ethiopia
Teklehaimanot, Awash
United States, New York
Earth Institute
Kiszewski, Anthony E.
United States, Waltham
Bentley College
Rampao, Herodes Sacramento
Sao Tome and Principe, São Tomé
Ministry of Health
Sachs, Jeffrey David
United States, New York
Earth Institute
Statistics
Citations: 78
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2009.80.133
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study