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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Evidence for subdivision within the M molecular form of Anopheles gambiae
Molecular Ecology, Volume 16, No. 3, Year 2007
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Description
The principal vector of malaria in sub-Saharan Africa, Anopheles gambiae is subdivided into two molecular forms M and S. Additionally, several chromosomal forms, characterized by the presence of various inversion polymorphisms, have been described. The molecular forms M and S each contain several chromosomal forms, including the Savanna, Mopti and Forest forms. The M and S molecular forms are now considered to be the reproductive units within A. gambiae and it has recently been argued that a low recombination rate in the centromeric region of the X chromosome has facilitated isolation between these forms. The status of the chromosomal forms remains unclear however. Therefore, we studied genetic differentiation between Savanna S, Forest S, Forest M and Mopti M populations using microsatellites. Genetic differentiation between Savanna S and Forest S populations is very low (FST = 0.0053 ± 0.0049), even across large distances. In comparison, the Mopti M and Forest M populations show a relatively high degree of genetic differentiation (FST = 0.0406 ± 0.0054) indicating that the M molecular form may not be a single entity, but could be subdivided into at least two distinct chromosomal forms. Previously it was proposed that inversions have played a role in the origin of species within the A. gambiae complex. We argue that a possible subdivision within the M molecular form could be understood through this process, with the acquisition of inversions leading to the expansion of the M molecular form into new habitat, dividing it into two distinct chromosomal forms. © 2006 The Authors.
Authors & Co-Authors
Slotman, Michel Andre
United States, New Haven
Yale University
United States, Davis
University of California, Davis
Tripét, Frédéric R.
United States, Davis
University of California, Davis
United Kingdom, Keele
Keele University
Cornel, Anthony John
United States, Davis
University of California, Davis
Meneses, Claudio
United States, Davis
University of California, Davis
Lee, Yoosook
United States, Los Angeles
University of California, Los Angeles
Reimer, Lisa J.
United States, Davis
University of California, Davis
Thiemann, T. C.
United States, Davis
University of California, Davis
Fondjo, Etienne
Cameroon, Yaounde
Ministry of Health
Fofana, Abdrahamane S.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Traoré, Sékou Fantamady
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Lanzaro, Gregory C.
United States, Davis
University of California, Davis
Statistics
Citations: 77
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1111/j.1365-294X.2006.03172.x
ISSN:
09621083
e-ISSN:
1365294X
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health