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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
New routes for the synthesis of 3- and 5-substituted 2(1H)-pyrazinones
Tetrahedron Letters, Volume 45, No. 9, Year 2004
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Description
Various 3-(hetero)aryl, 3-alkyl and 3-alkenyl-2(1H)-pyrazinones were prepared by applying the Suzuki and Heck reaction methodology to 3,5-dichloro-2(1H)-pyrazinones. Furthermore, following hydrogenolysis of the 5-chloro substituent and regioselective 5-bromination, this palladium-catalysed cross-coupling approach could be extended to the synthesis of the analogous 5-substituted 2(1H)-pyrazinones. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Azzam, Rasha A.
Belgium, Leuven
Ku Leuven
Egypt, Helwan
Faculty of Science
De Borggraeve, Wim M.
Belgium, Leuven
Ku Leuven
Compernolle, Frans C.
Belgium, Leuven
Ku Leuven
Hoornaert, Georges J.
Belgium, Leuven
Ku Leuven
Statistics
Citations: 21
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.tetlet.2004.01.017
ISSN:
00404039