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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Volume 505, No. 1-2, Year 2002
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Description
The human mannose-binding lectin (MBL) is an important protein of the innate immune system. MBL is able to eliminate potential pathogens by activating the complement cascade or by opsonisation. We investigated the gene and promoter region of MBL in a population from Papua New Guinea infected with Plasmodium falciparum parasites and measured the appropriate serum concentrations of these individuals. Their serum levels of MBL, detected by ELISA, showed a wide range with concentrations between 632 and 7325μg/l MBL. A known polymorphism in exon 1 at codon 54 causing an amino acid exchange from Gly to Asp occurred with a low frequency of 3%. Additional to the previously reported polymorphisms in the gene and promoter region of MBL, two novel polymorphic sites were found in the promoter region. One site was in the untranslated region of the MBL gene at position +1 (G⇒A, termed R/S), and the second was located upstream of the gene at position -4 (G⇒A, termed T/U). © 2002 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Jüliger, Simone
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Alpers, Michael Philip
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Reeder, John C.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Kun, Juergen F.J.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 12
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/S0027-5107(02)00142-2
ISSN:
00275107
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Guinea