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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Localization of candidate regions maintaining a common polymorphic inversion (2La) in Anopheles gambiae
PLoS Genetics, Volume 3, No. 12, Year 2007
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Description
Chromosomal inversion polymorphisms are thought to play a role in adaptive divergence, but the genes conferring adaptive benefits remain elusive. Here we study 2La, a common polymorphic inversion in the African malaria vector Anopheles gambiae. The frequency of 2La varies clinally and seasonally in a pattern suggesting response to selection for aridity tolerance. By hybridizing genomic DNA from individual mosquitoes to oligonucleotide microarrays, we obtained a complete map of differentiation across the A. gambiae genome. Comparing mosquitoes homozygous for the 2La gene arrangement or its alternative (2L+a), divergence was highest at loci within the rearranged region. In the 22 Mb included within alternative arrangements, two ∼1.5 Mb regions near but not adjacent to the breakpoints were identified as being significantly diverged, a conclusion validated by targeted sequencing. The persistent association of both regions with the 2La arrangement is highly unlikely given known recombination rates across the inversion in 2La heterozygotes, thus implicating selection on genes underlying these regions as factors responsible for the maintenance of 2La. Polymorphism and divergence data are consistent with a model in which the inversion is maintained by migration-selection balance between multiple alleles inside these regions, but further experiments will be needed to fully distinguish between the epistasis (coadaptation) and local adaptation models for the maintenance of 2La. © 2007 White et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2134946/bin/pgen.0030217.st001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2134946/bin/pgen.0030217.st002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2134946/bin/pgen.0030217.st003.doc
Authors & Co-Authors
White, Bradley J.
United States, Notre Dame
University of Notre Dame
Hahn, Matthew W.
United States, Bloomington
Luddy School of Informatics, Computing, and Engineering
Pombi, Marco
Italy, Rome
Sapienza Università Di Roma
Cassone, Bryan J.
United States, Notre Dame
University of Notre Dame
Lobo, Neil Francis
United States, Notre Dame
University of Notre Dame
Simard, Frédéric R.
France, Montpellier
Ird Centre de Montpellier
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endémies en Afrique Centrale
Besansky, Nora J.
United States, Notre Dame
University of Notre Dame
Statistics
Citations: 80
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pgen.0030217
e-ISSN:
15537404
Research Areas
Genetics And Genomics
Infectious Diseases