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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
mathematics
Comparison of HIV-1 and HIV-2 infectivity from a prospective cohort study in Senegal
Statistics in Medicine, Volume 22, No. 4, Year 2003
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Description
From a prospective cohort study of 1948 initially human immunodeficiency virus (HIV) uninfected female commercial sex workers followed between 1985 and 1999 in Dakar, Senegal, the authors compared the male to female per infectious sexual exposure transmission probability of HIV types one (HIV-1) and two (HIV-2). New non-parametric competing risks failure time methods were used, which minimized modelling assumptions and controlled for risk factors for HIV infection. The HIV-1 versus HIV-2 infectivity ratio over time was estimated by the ratio of smoothed non-parametric kernel estimates of the HIV-1 and HIV-2 infection hazard functions in sex workers, adjusted by an estimate of the relative HIV-1 versus HIV-2 prevalence in the partner population. HIV-1 was found to be significantly more infectious than HIV-2 throughout the follow-up period (P<0.001). The HIV-1/HIV-2 infectivity ratio was inferred to be approximately constant over time, with estimated common value 3.55. The finding of greater HIV-1 infectivity persisted in sensitivity analyses and in covariate-adjusted analyses, with adjusted infectivity ratio estimates ranging between 3.40 and 3.86. Understanding the mechanisms by which HIV-1 infects more efficiently than HIV-2 may be useful in the development of HIV-1 vaccines. Additionally, the methodology developed here may be useful for analysing other data sets. Copyright © 2003 John Wiley & Sons, Ltd.
Authors & Co-Authors
Gilbert, Peter B.
United States, Seattle
University of Washington
McKeague, Ian W.
United States, Tallahassee
Florida State University
Eisen, Geoffrey E.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Mullins, Christopher
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Guéye-Ndiaye, Aïssatou
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Mboup, Souleymane
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Kanki, Phyllis Jean
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Statistics
Citations: 173
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1002/sim.1342
ISSN:
02776715
Research Areas
Environmental
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal
Participants Gender
Male
Female