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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial BV2 cells
Biochemical and Biophysical Research Communications, Volume 446, No. 3, Year 2014
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Description
The objective of this study was to evaluate the biological activities of the major phytosterols present in argan oil (AO) and in cactus seed oil (CSO) in BV2 microglial cells. Accordingly, we first determined the sterol composition of AO and CSO, showing the presence of Schottenol and Spinasterol as major sterols in AO. While in CSO, in addition to these two sterols, we found mainly another sterol, the Sitosterol. The chemical synthesis of Schottenol and Spinasterol was performed. Our results showed that these two phytosterols, as well as sterol extracts from AO or CSO, are not toxic to microglial BV2 cells. However, treatments by these phytosterols impact the mitochondrial membrane potential. Furthermore, both Schottenol and Spinasterol can modulate the gene expression of two nuclear receptors, liver X receptor (LXR)-α and LXRβ, their target genes ABCA1 and ABCG1. Nonetheless, only Schottenol exhibited a differential activation vis-à-vis the nuclear receptor LXRβ. Thus Schottenol and Spinasterol can be considered as new LXR agonists, which may play protective roles by the modulation of cholesterol metabolism. © 2014 Elsevier Inc. All rights reserved.
Authors & Co-Authors
El Kharrassi, Youssef
France, Dijon
Laboratoire Bio-peroxil
Morocco, Settat
Faculté Des Sciences et Techniques Settat
Samadi, Mohammad
France, Nancy
Université de Lorraine
Lopez, T.
France, Dijon
Crinserm 866
Nury, Thomas
France, Dijon
Laboratoire Bio-peroxil
El Kebbaj, Riad
France, Dijon
Laboratoire Bio-peroxil
Morocco, Settat
Faculté Des Sciences et Techniques Settat
Andreoletti, Pierre
France, Dijon
Laboratoire Bio-peroxil
El Hajj, Hammam I.
France, Dijon
Laboratoire Bio-peroxil
Vamecq, Joseph
France, Paris
Inserm
Moustaid, Khadija
Morocco, Settat
Faculté Des Sciences et Techniques Settat
Latruffe, Norbert
France, Dijon
Laboratoire Bio-peroxil
El Kebbaj, M'Hammed Saïd
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Masson, David
France, Dijon
Crinserm 866
Lizard, Gérard
France, Dijon
Laboratoire Bio-peroxil
Nasser, Boubker
Morocco, Settat
Faculté Des Sciences et Techniques Settat
Cherkaoui-Malki, Mustapha
France, Dijon
Laboratoire Bio-peroxil
Statistics
Citations: 47
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1016/j.bbrc.2014.02.074
ISSN:
0006291X
e-ISSN:
10902104
Research Areas
Cancer
Environmental
Genetics And Genomics