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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model
Vaccine, Volume 26, No. 50, Year 2008
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Description
H5N1 highly pathogenic avian influenza viruses evolved into several clades, leading to appreciably distinct antigenicities of their hemagglutinins. As such, candidate H5N1 pre-pandemic vaccines for human use should be sought. Here, to evaluate fundamental immunogenic variations between H5N1 vaccines, we prepared four inactivated H5N1 test vaccines from different phylogenetic clades (clade 1, 2.1, 2.2, and 2.3.4) in accordance with the WHO recommendation, and tested their cross-clade immunity in a mouse model by vaccination followed by challenge with heterologous virulent viruses. All H5N1 vaccines tested provided full or partial cross-clade protective immunity, except one clade 2.2-based vaccine, which did not protect mice from clade 2.3.4 virus challenge. Among the test vaccines, a clade 2.1-based vaccine possessed the broadest-spectrum cross-immunity. These results suggest that currently stockpiled pre-pandemic vaccines, especially clade 2.1-based vaccines, will likely be useful as backup vaccines in a pandemic situation, even one involving antigenic-drifted viruses. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Iwatsuki-Horimoto, Kiyoko
Unknown Affiliation
Ito, Mutsumi
Unknown Affiliation
Kiso, Maki
Unknown Affiliation
Kida, Hiroshi
Japan, Sapporo
Hokkaido University
Takada, Ayato
Japan, Sapporo
Hokkaido University
Nidom, Chairul Anwar
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Mai, Lê Quynh
Indonesia, Surabaya
Universitas Airlangga
Yamada, Shinya
Unknown Affiliation
Sakai-Tagawa, Yuko T.
Unknown Affiliation
Kawaoka, Yoshihiro K.
Japan, Tokyo
The University of Tokyo
United States, Madison
University of Wisconsin-madison
Horimoto, Taisuke
Unknown Affiliation
Statistics
Citations: 24
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1016/j.vaccine.2008.08.053
ISSN:
0264410X