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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Malaria in pregnant Cameroonian women: The effect of age and gravidity on submicroscopic and mixed-species infections and multiple parasite genotypes
American Journal of Tropical Medicine and Hygiene, Volume 72, No. 3, Year 2005
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Description
Polymerase chain reaction (PCR)-based methods were used to investigate malaria in pregnant women residing in Yaoundé, Cameroon. Microscopy and species-specific PCR-based diagnosis show that at delivery 82.4% of the women were infected with Plasmodium falciparum (27.5% blood-smear positive and 54.9% submicroscopic infections). The prevalence of P. malariae and P. ovale was 7.6% and 2.5%, respectively, with 9.4% infected with more than one species. Based on genotyping of the merozoite surface protein 1 (msp-1) and msp-2 alleles, the mean number of genetically different P. falciparum parasites in peripheral blood was 3.4 (range = 1-9) and 3.5 (range 1-8) in the placenta. Plasmodium falciparum detected by microscopy and PCR as well as mixed-species infections were significantly higher in women ≤ 20 years old and paucigravidae. but maternal anemia was associated only with microscopic detection of parasites. Neither submicroscopic infections nor number of parasite genotypes decreased significantly with age or gravidity. Thus, pregnancy-associated immunity helps reduce malaria to submicroscopic levels, but does not reduce the number of circulating parasite genotypes. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Walker-Abbey, Annie
United States, Washington, D.c.
Georgetown University
Djokam, Rosine R.T.
Cameroon, Yaounde
Université de Yaoundé I
Eno, Anna A.
Cameroon, Yaounde
Université de Yaoundé I
Léké, Rose Gana Fomban
Cameroon, Yaounde
Université de Yaoundé I
Titanji, Vincent Pryde Kehdinga
Cameroon, Yaounde
Université de Yaoundé I
Fogako, Josephine
Cameroon, Yaounde
Université de Yaoundé I
Sama, Grace
Cameroon, Yaounde
Université de Yaoundé I
Thuita, Lucy W.
United States, Washington, D.c.
Georgetown University
Beardslee, Eliza
United States, Washington, D.c.
Georgetown University
Snounou, Georges
France, Paris
Cnrs Centre National de la Recherche Scientifique
Zhou, Ainong
United States, Rockville
Az Dataclinic, Inc.
Taylor, Diane Wallace
United States, Washington, D.c.
Georgetown University
Statistics
Citations: 118
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2005.72.229
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Cameroon
Participants Gender
Female