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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
CAPRISA 004 tenofovir microbicide trial: No impact of tenofovir gel on the HIV transmission bottleneck
Journal of Infectious Diseases, Volume 206, No. 1, Year 2012
Notification
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Description
Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus-infected source host to the newly infected individual. We used heteroduplex tracking assay and single-genome sequencing to investigate the effect of a tenofovir-based microbicide gel on the transmission bottleneck in women who seroconverted during the CAPRISA 004 microbicide trial. Seventy-seven percent (17 of 22; 95 confidence interval [CI], 56-90) of women in the tenofovir gel arm were infected with a single virus compared with 92 (13 of 14; 95 CI, 67->99) in the placebo arm (P =. 37). Tenofovir gel had no discernable impact on the transmission bottleneck. © 2012 The Author.
Authors & Co-Authors
Valley-Omar, Ziyaad
South Africa, Cape Town
University of Cape Town
Sibeko, Sengeziwe Sibongile
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Anderson, Jeffrey A.
United States, Charlotte
The University of North Carolina at Charlotte
Goodier, Sarah A.M.
South Africa, Cape Town
University of Cape Town
Werner, Lise
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Arney, Leslie A.
United States, Charlotte
The University of North Carolina at Charlotte
Naranbhai, Vivek
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Treurnicht, F. K.
South Africa, Cape Town
University of Cape Town
Rose-Abrahams, Melissa
South Africa, Cape Town
University of Cape Town
Bandawe, Gama P.
South Africa, Cape Town
University of Cape Town
Swanstrom, Ronald I.
United States, Charlotte
The University of North Carolina at Charlotte
Abdool Karim, Quarraisha Abdool
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Columbia University
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 16
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jis305
ISSN:
00221899
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female