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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease
Virology, Volume 485, Year 2015
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Description
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication. © 2015.
Authors & Co-Authors
Johnson, Reed F.
United States, Bethesda
National Institutes of Health Nih
Via, L. E.
United States, Bethesda
National Institutes of Health Nih
Postnikova, Elena N.
United States, Bethesda
National Institutes of Health Nih
Ork, Britini L.
United States, Bethesda
National Institutes of Health Nih
Holbrook, Michael R.
United States, Bethesda
National Institutes of Health Nih
Johnson, Joshua C.
United States, Bethesda
National Institutes of Health Nih
Hensley, Lisa E.
United States, Bethesda
National Institutes of Health Nih
Jährling, Peter B.
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 45
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1016/j.virol.2015.07.013
ISSN:
00426822
Research Areas
Covid