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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The role of SNPs in the α-chain of the IL-7R gene in CD4 T-cell recovery in HIV-infected African patients receiving suppressive cART
Genes and Immunity, Volume 13, No. 1, Year 2012
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Description
We previously found an association between faster CD4+ T-cell recovery in HIV-infected patients receiving combination antiretroviral therapy (cART) and interleukin-7 receptor-α (IL-7Rα) haplotype-2 in a predominantly Caucasian cohort. This study aims to determine whether this association was also significant in Africans. Patients were recruited from the Uganda AIDS Rural Treatment Outcomes (UARTO) cohort (n=352). We used survival analysis and linear mixed modelling (LMM) to determine factors associated with CD4 T-cell recovery. Eight IL-7Rα single-nucleotide polymorphisms (SNPs) were genotyped in both Africans and Caucasians (n=57). Soluble (s)IL-7Rα levels were measured by ELISA. In UARTO, IL-7Rα haplotype-2 was associated with slower CD4 T-cell recovery following cART by using survival analysis (P=0.020) and no association was found with LMM (P=0.958). The tagging-SNP for IL-7Rα haplotype-2 (rs6897932) was associated with decreased sIL-7Rα (P0.001). The haplotypes for the IL-7Rα were significantly different in Africans and Caucasians. Using IL-7Rα genotypes we found slower CD4 T-cell recovery in UARTO patients was still associated with rs6897932 (P=0.009) and rs3194051 was associated with faster CD4 T-cell recovery (P=0.006). Unlike Caucasians, we did not demonstrate a significant association between IL-7Rα haplotype 2 and faster CD4 T-cell recovery in Africans. The IL-7Rα SNPs associated with CD4 T-cell recovery following cART differ in African and Caucasian cohorts. © 2012 Macmillan Publishers Limited All rights reserved.
Authors & Co-Authors
Rajasuriar, R.
Australia, Clayton
Monash University
Malaysia, Kuala Lumpur
Universiti Malaya
Booth, David R.
Australia, Sydney
The University of Sydney
Gouillou, Maelenn
Australia, Melbourne
Burnet Institute
Spelman, Tim D.
Australia, Clayton
Monash University
Australia, Melbourne
Burnet Institute
James, Ian R.
Australia, Perth
Murdoch University
Solomon, Ajantha E.
Australia, Clayton
Monash University
Chua, K.
Australia, Clayton
Monash University
Stewart, G.
Australia, Sydney
The University of Sydney
Deeks, Steven G.
United States, San Francisco
University of California, San Francisco
Bangsberg, David R.
United States, Boston
Massachusetts General Hospital
Uganda, Mbarara
Mbarara University of Science and Technology
Muzoora, Conrad K.
Uganda, Mbarara
Mbarara University of Science and Technology
Cameron, Paul U.
Australia, Clayton
Monash University
Australia, Melbourne
Burnet Institute
Australia, Melbourne
Infectious Diseases Unit
Hunt, Peter W.
United States, San Francisco
University of California, San Francisco
Martin, Jeffrey N.
United States, San Francisco
University of California, San Francisco
Lewin, Sharon R.
Australia, Clayton
Monash University
Australia, Melbourne
Burnet Institute
Australia, Melbourne
Infectious Diseases Unit
Statistics
Citations: 31
Authors: 15
Affiliations: 9
Identifiers
Doi:
10.1038/gene.2011.65
ISSN:
14664879
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
Uganda