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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pregnancy outcomes in women exposed to efavirenz and nevirapine: An appraisal of the IeDEA West Africa and ANRS databases, abidjan, Côte d'Ivoire
Journal of Acquired Immune Deficiency Syndromes, Volume 56, No. 2, Year 2011
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Description
Background: An increasing number of HIV-infected women become pregnant while receiving efavirenz (EFV). We compared the pregnancy outcomes of women exposed to EFV and to nevirapine (NVP) during the first trimester. Methods: A retrospective study in 4 HIV care centers participating to clinical trials and international cohort collaboration. All HIV-infected pregnant women who conceived on EFV-based or NVP-based antiretroviral therapy (ART) between 2003 and 2009 were included. Pregnancy outcomes were as follows: abortion (voluntary termination), miscarriage [unwanted termination <20 weeks of amenorrhea (WA)], stillborn (death ≥20 WA), preterm delivery (live-birth <37 WA), and low birth weight (LBW) (<2500 grams). Results: Overall, 344 HIV-infected pregnant women conceived on ART (213 on EFV and 131 on NVP). Median age was 29 years, and median CD4 count 217 cells per microliter at ART initiation. The overall proportion was 11.7% for abortion, 5.2% for miscarriage, 6.7% for stillborn, 10.8% for preterm delivery, and 20.2% for LBW. There was no difference between EFV and NVP exposure, except for abortion (14.3% vs 7.3%; P = 0.05). No external and visible congenital malformation was observed neither in women exposed to EFV nor in women exposed to NVP. Conclusions: Among women exposed to EFV, no significant increased risk of unfavorable pregnancy outcome was reported except for abortion. © 2011 Lippincott Williams & Wilkins.
Authors & Co-Authors
Ékouévi, Didier Koumavi
Cote D'ivoire, Abidjan
Programme Pac-ci
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Coffié, Patrick Ahuatchi
Cote D'ivoire, Abidjan
Programme Pac-ci
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Ouattara, Éric N.
Cote D'ivoire, Abidjan
Programme Pac-ci
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Moh, Raoul D.
Cote D'ivoire, Abidjan
Programme Pac-ci
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Amani-Bossé, Clarisse
Cote D'ivoire, Abidjan
Aconda
Messou, Eugéne
Cote D'ivoire, Abidjan
Programme Pac-ci
Cote D'ivoire, Abidjan
Centre de Prise en Charge de Recherche et de Formation
Sissoko, Marcel
Cote D'ivoire, Abidjan
Centre Intégré de Recherche Biomédicale Abidjan Cirba
Anglaret, Xavier
Cote D'ivoire, Abidjan
Programme Pac-ci
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Programme Pac-ci
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Danel, Christine
Cote D'ivoire, Abidjan
Programme Pac-ci
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Dabis, Franćois Ç.Ois
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Statistics
Citations: 70
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1097/QAI.0b013e3181ff04e6
ISSN:
15254135
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Multi-countries
Ivory Coast
Participants Gender
Female