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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The impact of malaria in pregnancy on changes in blood pressure in children during their first year of life
Hypertension, Volume 63, No. 1, Year 2014
Notification
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Description
We established a maternal birth cohort in Ibadan, Nigeria, where malaria is hyperendemic, to assess how intrauterine exposure to malaria affected infant blood pressure (BP) development. In a local maternity hospital, healthy pregnant women had regular blood films for malaria parasites from booking to delivery. Growth and BP were measured on 318 babies, all followed from birth to 3 and 12 months. Main outcomes were standardized measures of anthropometry and change in BP to 1 year. Babies exposed to maternal malaria were globally smaller at birth, and boys remained smaller at 3 months and 1 year. Change in systolic BP (SBP) during the year was greater in boys than in girls (20.9 versus 15.7 mm Hg; P=0.002) but greater in girls exposed to maternal malaria (18.7 versus 12.7 mm Hg; 95% confidence interval, 1-11 mm Hg; P=0.02). Eleven percent of boys (greater than twice than expected) had a SBP ≥95th percentile (hypertensive, US criteria), of whom 68% had maternal malaria exposure. On regression analysis (β coefficients, mm Hg), sex (boys>girls; β=4.4; 95% confidence interval, 1.1-7.7; P=0.01), maternal malaria exposure (3.64; 0.3-6.9; P=0.03), and weight change (2.4; 0.98-3.8/1 standard deviation score; P=0.001) all independently increased SBP change to 1 year, whereas increase in length decreased SBP (-1.98; -3.6 to -0.40). In conclusion, malaria-exposed boys had excess hypertension, whereas malaria-exposed girls a greater increase in SBP. Intrauterine exposure to malaria had sex-dependent effects on BP, independent of infant growth. Because infant-child-adult BP tracking is powerful, a malarial effect may contribute to the African burden of hypertension. © 2013 American Heart Association, Inc.
Authors & Co-Authors
Ayoola, Omolola Ouwakemi
United Kingdom, Manchester
The University of Manchester
Omotade, Olayemi O.
Nigeria, Ibadan
University of Ibadan
Gemmell, Isla
United Kingdom, Manchester
The University of Manchester
Clayton, Peter E.
United Kingdom, Manchester
The University of Manchester
Cruickshank, J. Kennedy
United Kingdom, London
King's Health Partners
Statistics
Citations: 22
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1161/HYPERTENSIONAHA.113.02238
ISSN:
0194911X
e-ISSN:
15244563
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Nigeria
Participants Gender
Male
Female