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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants
Retrovirology, Volume 10, No. 1, Article 3, Year 2013
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Description
Background: Breastfeeding is a leading cause of infant HIV-1 infection in the developing world, yet only a minority of infants exposed to HIV-1 via breastfeeding become infected. As a genetic bottleneck severely restricts the number of postnatally-transmitted variants, genetic or phenotypic properties of the virus Envelope (Env) could be important for the establishment of infant infection. We examined the efficiency of virologic functions required for initiation of infection in the gastrointestinal tract and the neutralization sensitivity of HIV-1 Env variants isolated from milk of three postnatally-transmitting mothers (n=13 viruses), five clinically-matched nontransmitting mothers (n=16 viruses), and seven postnatally-infected infants (n = 7 postnatally-transmitted/founder (T/F) viruses).Results: There was no difference in the efficiency of epithelial cell interactions between Env virus variants from the breast milk of transmitting and nontransmitting mothers. Moreover, there was similar efficiency of DC-mediated trans-infection, CCR5-usage, target cell fusion, and infectivity between HIV-1 Env-pseudoviruses from nontransmitting mothers and postnatal T/F viruses. Milk Env-pseudoviruses were generally sensitive to neutralization by autologous maternal plasma and resistant to breast milk neutralization. Infant T/F Env-pseudoviruses were equally sensitive to neutralization by broadly-neutralizing monoclonal and polyclonal antibodies as compared to nontransmitted breast milk Env variants.Conclusion: Postnatally-T/F Env variants do not appear to possess a superior ability to interact with and cross a mucosal barrier or an exceptional resistance to neutralization that define their capability to initiate infection across the infant gastrointestinal tract in the setting of preexisting maternal antibodies. © 2013 Fouda et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3564832/bin/1742-4690-10-3-S1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3564832/bin/1742-4690-10-3-S2.pdf
Authors & Co-Authors
Fouda, Genevieve G.A.
United States, Durham
Duke University Medical Center
Mahlokozera, Tatenda
United States, Durham
Duke University Medical Center
Salazar-González, Jesús Fidel
United States, Birmingham
The University of Alabama at Birmingham
Salazar, Maria G.
United States, Birmingham
The University of Alabama at Birmingham
Learn, Gerald H.
United States, Philadelphia
University of Pennsylvania
Kumar, Surender B.
United States, Columbus
The Ohio State University
Dennison, S. Moses
United States, Durham
Duke University Medical Center
Russell, Elizabeth S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Rizzolo, Katherine
United States, Boston
Beth Israel Deaconess Medical Center
Jaeger, Frederick H.
United States, Durham
Duke University Medical Center
Cai, Fangping
United States, Durham
Duke University Medical Center
Vandergrift, Nathan A.
United States, Durham
Duke University Medical Center
Gao, Feng
United States, Durham
Duke University Medical Center
Hahn, Beatrice H.
United States, Philadelphia
University of Pennsylvania
Shaw, George M.
United States, Philadelphia
University of Pennsylvania
Ochsenbauer, Christina
United States, Birmingham
The University of Alabama at Birmingham
Swanstrom, Ronald I.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Meshnick, Steven Richard
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mwapasa, Victor
Malawi, Zomba
University of Malawi
Kalilani-Phiri, Linda V.
Malawi, Zomba
University of Malawi
Fiscus, Susan A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Montefiori, David Charles
United States, Durham
Duke University Medical Center
Haynes, Barton F.
United States, Durham
Duke University Medical Center
Kwiek, Jesse J.
United States, Columbus
The Ohio State University
Alam, S. Munir
United States, Durham
Duke University Medical Center
Permar, Sallie Robey
United States, Durham
Duke University Medical Center
Statistics
Citations: 26
Authors: 26
Affiliations: 7
Identifiers
Doi:
10.1186/1742-4690-10-3
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health