Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Anaemia and zidovudine-containing antiretroviral therapy in paediatric antiretroviral programmes in the IeDEA Paediatric West African Database to evaluate AIDS
Journal of the International AIDS Society, Volume 16, Article 18024, Year 2013
Notification
URL copied to clipboard!
Description
Introduction: There is a risk of anaemia among HIV-infected children on antiretroviral therapy (ART) containing zidovudine (ZDV) recommended in first-line regimens in the WHO guidelines. We estimated the risk of severe anaemia after initiation of a ZDV-containing regimen in HIV-infected children included in the IeDEA West African database. Methods: Standardized collection of data from HIV-infected children (positive PCR < 18 months or positive serology ≥18 months) followed up in HIV programmes was included in the regional IeDEA West Africa collaboration. Ten clinical centres from seven countries contributed (Benin, Burkina Faso, Côte d'Ivoire, Gambia, Ghana, Mali and Senegal) to this collection. Inclusion criteria were age <16 years and starting ART. We explored the data quality of haemoglobin documentation over time and the incidence and predictors of severe anaemia (Hb <7g/dL) per 100 child-years of follow-up over the duration of first-line antiretroviral therapy. Results: As of December 2009, among the 2933 children included in the collaboration, 45% were girls, median age was five years; median CD4 cell percentage was 13%; median weight-for-age z-score was -2.7; and 1772 (60.4%) had a first-line ZDV-containing regimen. At baseline, 70% of the children with a first-line ZDV-containing regimen had a haemoglobin measure available versus 76% in those not on ZDV (p ≤0.01): the prevalence of severe anaemia was 3.0% (n =38) in the ZDV group versus 10.2% (n =89) in those without (p <0. 01). Over the first-line follow-up, 58.9% of the children had ≥1 measure of haemoglobin available in those exposed to ZDV versus 60.4% of those not (p =0.45). Severe anaemia occurred in 92 children with an incidence of 2.47 per 100 child-years of follow-up in those on a ZDV-containing regimen versus 4.25 in those not (p ≤0.01). Adjusted for age at ART initiation and first-line regimen, a weight-for-age z-score ≤-3 was a strong predictor associated with a 5.59 times risk of severe anaemia (p<0.01). Conclusions: Severe anaemia is frequent at baseline and guides the first-line ART prescription, but its incidence seems rare among children on ART. Severe malnutrition at baseline is a strong predictor for development of severe anaemia, and interventions to address this should form an integral component of clinical care. © 2013 Renner LA et al; licensee International AIDS Society.
Authors & Co-Authors
A Renner, Lorna
Ghana, Accra
University of Ghana
Dicko-Traoré, Fatoumata B.
Mali, Bamako
Hopital Gabriel Toure
Kouéta, Fla
Burkina Faso, Ouagadougou
Chu Pédiatrique Charles-de-gaulle
Malateste, Karen
France, Paris
Inserm
Gueye, Ramatoulaye Diagne
Senegal, Dakar
Hopital D'enfants Albert-royer Dakar
Aka, Edmond Addi
Cote D'ivoire, Abidjan
De Recherche et de Formation Cepref
Eboua, Tanoh Kassi François
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Azondékon, Alain
Benin, Cotonou
Hôpital D'instruction Des Armées de Cotonou
Okomo, Uduak A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Touré, Pety
Cote D'ivoire, Abidjan
Centre Mtct-plus
Ékouévi, Didier Koumavi
Cote D'ivoire, Abidjan
Operations Research Iedea
Leroy, Valeriane
France, Paris
Inserm
Statistics
Citations: 27
Authors: 12
Affiliations: 11
Identifiers
Doi:
10.7448/IAS.16.1.18024
e-ISSN:
17582652
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Multi-countries
Benin
Burkina Faso
Gambia
Ghana
Ivory Coast
Mali
Senegal
Participants Gender
Female