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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nail changes in patients with liver disease
Journal of the European Academy of Dermatology and Venereology, Volume 24, No. 6, Year 2010
Notification
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Description
Background Liver cirrhosis, hepatitis C virus (HCV) and hepatitis B (HBV) virus infections are known to be associated with different skin disorders. Nail changes are additional important criteria, which would help in identification of these systemic diseases. Objective To record the nail abnormalities in patients with liver disease which were not reported before, especially those with HCV and HBV infection. Patients and methods The study comprised 100 patients with HCV, HBV and liver cell failure, and 100 normal healthy controls. Both groups underwent full history taking and thorough general examination, complete blood picture, hepatitis B antigen, hepatitis C antibody, liver function tests, abdominal ultrasonography and PCR were performed in patients with liver disease. Full nail examination was performed. Results Nail changes were more prevalent in patient group (68%) than in the control group (35%). The nail infection, onychomycosis, was the most common finding in 18% of patients and that in controls was 10% followed by in a descending order, longitudinal striations, brittle nails, onychorrhexis, clubbing of fingers, dystrophic nails, leukonychia and longitudinal melanonychia. Conclusion Nail changes are observed with not only liver cirrhosis but also with HCV and HBV infection, and this will add additional clinical criteria for general practitioners and dermatologists to help them with diagnosis of these common systemic infections. © 2009 European Academy of Dermatology and Venereology.
Authors & Co-Authors
Salem, Ahmed M.H.
Egypt, Zagazig
Zagazig University
Gamil, Hend Darwish
Egypt, Zagazig
Zagazig University
Hamed, M.
Egypt, Zagazig
Zagazig University
Galal, Sherif M.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Statistics
Citations: 30
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1111/j.1468-3083.2009.03476.x
ISSN:
09269959
e-ISSN:
14683083
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study