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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Restorative valve therapy by endogenous tissue restoration: Tomorrow's world? Reflection on the EuroPCR 2017 session on endogenous tissue restoration
EuroIntervention, Volume 13, Year 2017
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Description
The current standard of treatment of valvular diseases with severe functional and/or clinical consequences is the repair or replacement of the valve, which is usually surgical or, in specific scenarios, percutaneous. The available prosthetic valves, however, are not a magic bullet in the physicians' arsenal for the management of valvular diseases, since the age-dependent structural valve deterioration (SVD) and the need for prolonged systemic anticoagulation in the case of metallic prosthetic valves are not inconsequential during the lifespan of a patient with an implanted prosthetic valve. Based on decades of research combining the scientific disciplines of supramolecular chemistry, electrospinning and regenerative medicine, endogenous tissue restoration has emerged as a very promising domain to provide this magic bullet, in the form of valves, which enables functional restoration by the body itself. The concept of a restorative material that will set the framework for the creation of a new, endogenous valve is very appealing and, recently, proof of concept studies have been completed at both preclinical and clinical levels. These studies have shown favourable pathologic, anatomic and haemodynamic characteristics compared to currently available prosthetic valves, in sheep and in young children undergoing right ventricular outflow tract reconstruction, and may represent an alternative to the bioprosthesis made of xenopericardial tissue. The present manuscript reviews the rationale, background knowledge and historic development of endogenous tissue restoration and presents preliminary data about the Xeltis valve, which appears to have the potential to make restorative valve therapy a reality in clinical practice. © 2017 Europa Digital & Publishing. All rights reserved.
Authors & Co-Authors
Serruys, Patrick W.
United Kingdom, London
Imperial College London
Miyazaki, Yosuke
Netherlands, Rotterdam
Erasmus Mc
Abdelghani, Mohammad
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Leon, Martin B.
United States, New York
New York Presbyterian Hospital
Virmani, Renu
United States, Gaithersburg
Cvpath Institute, Inc.
Carrel, Thierry Pierre
Switzerland, Bern
University Hospital Bern
Onuma, Yosinobu
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Rotterdam
Cardialysis bv
Soliman, O. I.I.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Rotterdam
Cardialysis bv
Statistics
Citations: 26
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.4244/EIJ-D-17-00509
ISSN:
1774024X
Research Areas
Health System And Policy
Maternal And Child Health