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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Longitudinal study of seroreactivities to Pf 155/RESA and its repetitive sequences in small children from a holoendemic area of Liberia
Parasite Immunology, Volume 13, No. 3, Year 1991
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Description
Summary Summary The seroreactivities to Pf 155/RESA antigen and to three oligopeptides (EENV)2, EENVEHDA and K(DDEHVEEPTVA)2, which constitute repeal subunits of the RESA molecule, were investigated between 1980 and 1986 in two cohorts of children (n= 114) with and without monthly chemosuppression (pulsed reduction of parasite load) against malaria from six months to five years of age during development of protective immunity. Serum samples were collected first at half‐yearly and then yearly intervals. Positive immunofluorescence against Pf 155/ RESA (EMIF) was only found in 24% of the samples. The children with chemosuppression were more often seropositive (30%) than the non prophylactic children (17%). This was in contrast to the seroreactivity against crude parasitic antigens which was highest in the non prophylactic children. In these children, there was a general decrease of EMIF litres around two years of age. Immunosuppression by chronic parasitaemia may be suggested as a reason for this. ELISA seroreactivity was found against one, two or three oligopeptides in all children with high EMIF titres (>250) although (EENV)2 appeared to best correlate (92%) with the EMIF seropositivity. While EMIF seropositivity only showed partial correlation to immunoprotection against patent parasitaemia in the non prophylactic children, the individual profiles of the seroreactivities to the different specific epitopes of the Pf 155/RESA molecule and their relevance with regards to protective immunity to malaria need to be investigated further. Copyright © 1991, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Bjǒrkman, Anders B.
Liberia
Liberian Institute of Biomedical Research
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Lebbad, Marianne
Liberia
Liberian Institute of Biomedical Research
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Perlmann, Hedvig K.
Sweden, Stockholm
Stockholms Universitet
FREEMAN, T.
Liberia
Liberian Institute of Biomedical Research
Högh, Birthe
Liberia
Liberian Institute of Biomedical Research
Sweden, Stockholm
Stockholms Universitet
Petersen, Eskild
Liberia
Liberian Institute of Biomedical Research
Sweden, Stockholm
Karolinska Universitetssjukhuset
Gille, Elena
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
LINDGREN, A.
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Willcox, Michael C.
Liberia
Liberian Institute of Biomedical Research
Hanson, A. P.
Liberia
Liberian Institute of Biomedical Research
Perlmann, Peter H.
Liberia
Liberian Institute of Biomedical Research
Sweden, Stockholm
Stockholms Universitet
Statistics
Citations: 11
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-3024.1991.tb00284.x
ISSN:
01419838
e-ISSN:
13653024
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Liberia