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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Campylobacter Infection in Children in Malawi Is Common and Is Frequently Associated with Enteric Virus Co-Infections
PLoS ONE, Volume 8, No. 3, Article e59663, Year 2013
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Description
Background: Campylobacter species are the most common cause of bacterial gastroenteritis in the developed world. However, comparatively few studies have determined the epidemiological features of campylobacteriosis in resource-poor settings. Methods: A total of 1,941 faecal specimens collected from symptomatic (diarrhoeic) children and 507 specimens from asymptomatic (non-diarrhoeic) children hospitalised in Blantyre, Malawi, between 1997 and 2007, and previously tested for the presence of rotavirus and norovirus, was analysed for C. jejuni and C. coli using a real time PCR assay. Results: Campylobacter species were detected in 415/1,941 (21%) of diarrhoeic children, with C. jejuni accounting for 85% of all cases. The median age of children with Campylobacter infection was 11 months (range 0.1-55 months), and was significantly higher than that for children with rotavirus and norovirus (6 months and 7 months respectively; P<0.001). Co-infection with either rotavirus or norovirus was noted in 41% of all cases in the diarrhoeic group. In contrast, the detection rate of Campylobacter in the non-diarrhoeic group was 14%, with viral co-infection identified in 16% of children with Campylobacter. There was no association between Campylobacter detection rate and season over the 10 year period. Discussion: Using molecular detection methodology in hospitalised Malawian children, we have demonstrated a high prevalence of Campylobacter infection, with frequent viral co-infection. The burden of Campylobacter infection in young African children may be greater than previously recognised. © 2013 Mason et al.
Authors & Co-Authors
Mason, Jenifer
United Kingdom, Liverpool
University of Liverpool
Iturriza-Gómara, Miren
United Kingdom, Liverpool
University of Liverpool
O'Brien, Sarah J.
United Kingdom, Liverpool
University of Liverpool
Ngwira, Bagrey M.M.
Malawi, Zomba
University of Malawi
Dove, Winifred
United Kingdom, Liverpool
University of Liverpool
Maiden, Martin Christopher James
United Kingdom, Oxford
University of Oxford
Cunliffe, Nigel A.
United Kingdom, Liverpool
University of Liverpool
Statistics
Citations: 50
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0059663
e-ISSN:
19326203
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Malawi