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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Haploidentical stem cell transplantation as a salvage therapy for cord blood engraftment failure in a patient with fanconi anemia
Pediatric Blood and Cancer, Volume 55, No. 3, Year 2010
Notification
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Description
A 7-year-old male with Fanconi Anemia who developed primary graft failure following one antigen-mismatched unrelated cord blood transplantation and a nonradiation-based conditioning, underwent a second hematopoietic stem cell transplantation (HSCT) from his 2-loci mismatched haploidentical father, using a nonradiation-based regimen, 79 days after the first HSCT. A sustained hematological engraftment was achieved at 9 days post-second HSCT. At 15 months post-second HSCT; the patient demonstrated normal blood counts, sustained donor chimerism, and no evidence of GVHD. Haploidentical HSCTs as primary or secondary sources of stem cells, with appropriate T-cell depletion, may be a readily available option in the absence of HLA-matched related or unrelated donors. © 2010 Wiley-Liss, Inc.
Authors & Co-Authors
Rihani, Rawad
Jordan, Amman
King Hussein Cancer Center
Lataifeh, Isam
Jordan, Irbid
Jordan University of Science and Technology
Halalsheh, Hadeel
Jordan, Amman
King Hussein Cancer Center
Hussein, Ayad Ahmed
Jordan, Amman
King Hussein Cancer Center
Al-Zaben, Abdulhadi
Jordan, Amman
King Hussein Cancer Center
Abdel-Rahman, Fawzi Latif
Jordan, Amman
King Hussein Cancer Center
Sarhan, Mahmoud M.
Jordan, Amman
King Hussein Cancer Center
Statistics
Citations: 7
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1002/pbc.22584
ISSN:
15455009
e-ISSN:
15455017
Research Areas
Cancer
Health System And Policy
Participants Gender
Male