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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A randomized comparative trial of adriamycin versus methotrexate in combination drug therapy
Cancer, Volume 41, No. 5, Year 1978
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Description
A prospective randomized trial was conducted comparing the clinical response of 78 previously untreated patients with advanced metastatic breast cancer to a combination of cyclophosphamide, methotrexate, and 5‐fluorouracil (CMF) or to a combination of cyclophosphamide, adriamycin, and 5‐fluorouracil (CAF). Sixty‐two percent of the patients receiving CMF responded to treatment compared to an 82% response rate for the patients receiving CAF. Although within acceptable limits, hematologic and GI toxicity was greater with CAF. There was no significant difference in the duration of response to the two regimens. Therefore, the therapeutic difference between the two therapies is a higher initial response rate to the adriamycin containing regimen. Copyright © 1978 American Cancer Society
Authors & Co-Authors
Bull, Joan M.C.
United States, Rockville
National Cancer Institute Nci
Tormey, Douglass C.
United States, Rockville
National Cancer Institute Nci
Li, Shou‐Hua ‐H
United States, Rockville
National Cancer Institute Nci
Carbone, Paul P.
United States, Rockville
National Cancer Institute Nci
Falkson, Geoffrey G.
South Africa, Pretoria
University of Pretoria
Blom, Johannes
United States, Bethesda
Walter Reed National Military Medical Center
Perlin, Elliott
United States, Bethesda
Walter Reed National Military Medical Center
Simon, Richard M.
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 230
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/1097-0142(197805)41:5<1649::AID-CNCR2820410501>3.0.CO;2-J
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Study Design
Cohort Study