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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent
Pharmacogenomics Journal, Volume 14, No. 2, Year 2014
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Description
There is established clinical evidence for differences in drug response, cure rates and survival outcomes between different ethnic populations, but the causes are poorly understood. Differences in frequencies of functional genetic variants in key drug response and metabolism genes may significantly influence drug response differences in different populations. To assess this, we genotyped 1330 individuals of African (n=372) and European (n=958) descent for 4535 single-nucleotide polymorphisms in 350 key drug absorption, distribution, metabolism, elimination and toxicity genes. Important and remarkable differences in the distribution of genetic variants were observed between Africans and Europeans and among the African populations. These could translate into significant differences in drug efficacy and safety profiles, and also in the required dose to achieve the desired therapeutic effect in different populations. Our data points to the need for population-specific genetic variation in personalizing medicine and care. © 2014 Macmillan Publishers Limited.
Authors & Co-Authors
Aminkeng, Folefac
Canada, Vancouver
The University of British Columbia
Ross, Colin J.D.
Canada, Vancouver
The University of British Columbia
Rassekh, S. R.
Canada, Vancouver
The University of British Columbia
Brunham, Liam R.
Canada, Vancouver
The University of British Columbia
Singapore, Singapore City
National University of Singapore
Sistonen, J.
Canada, Vancouver
The University of British Columbia
Switzerland, Bern
University Hospital Bern
Dubé, Marie Pierre
Canada, Montreal
Institut de Cardiologie de Montreal
Ibrahim, Muntaser Eltayeb
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Nyambo, Thomas B.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Omar, Sabah Ahmed
Kenya, Nairobi
Kenya Medical Research Institute
Froment, Alain
France, Paris
Museé de L'homme
Bodo, Jean Marie
Cameroon, Yaounde
Ministère de la Recherche Scientifique et de L'innovation
Tishkoff, Sarah A.
United States, Philadelphia
University of Pennsylvania
Carleton, Bruce C.
Canada, Vancouver
The University of British Columbia
Hayden, Michael R.
Canada, Vancouver
The University of British Columbia
Singapore, Singapore City
National University of Singapore
Statistics
Citations: 32
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1038/tpj.2013.13
ISSN:
1470269X
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study