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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Factors associated with CD4 lymphocyte counts in HIV-negative Senegalese individuals
Clinical and Experimental Immunology, Volume 151, No. 3, Year 2008
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Description
CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and genetic factors that probably persist throughout the course of HIV infection. This study sought to determine reference levels and identify factors that influence lymphocyte counts in 681 HIV-uninfected adults in Senegal, where residents are exposed to a variety of infectious diseases and other conditions that may affect CD4 counts. Lymphocyte counts were assessed in commercial sex workers, symptomatic men and women presenting to the University of Dakar infectious disease clinic for out-patient care and women seeking family planning services. CD4 and CD3 lymphocyte counts differed between the four study groups (P < 0.01). Men had the lowest mean CD4 count (711.6 cells/μl), while commercial sex workers had the highest levels (966.0 cells/μl). After adjustment for age and other behavioural and clinical factors, the difference in CD4 counts between the three groups of women did not remain. However, both gender and smoking were associated independently with CD4 counts, as men maintained lower mean CD4 counts (β = -156.4 cells/μl, P < 0.01) and smokers had higher mean CD4 counts (β = 124.0 cells/μl, P < 0.01) than non-smokers in multivariable analyses. This study is the first to explore factors that may influence CD4 levels in Senegal and to estimate baseline CD4 levels among HIV-negatives, information that may guide clinicians in interpreting CD4 counts. © 2007 The Author(s).
Authors & Co-Authors
Mair, C.
United States, Seattle
University of Washington
Hawes, Stephen Edward
United States, Seattle
University of Washington
Agne, Habibatou D.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sow, Papa Salif
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
N'Doye, Ibraham
Senegal, Dakar
Institut Dhygiène Sociale Dakar
Manhart, Lisa E.
United States, Seattle
University of Washington
Fu, P. L.
United States, San Francisco
Lumetra
Gottlieb., Geoffrey S.
United States, Seattle
University of Washington School of Medicine
Kiviat, Nancy B.
United States, Seattle
University of Washington School of Medicine
Statistics
Citations: 55
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-2249.2007.03573.x
ISSN:
00099104
e-ISSN:
13652249
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Locations
Senegal
Participants Gender
Male
Female