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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Human adaptation and diversification in the Microsporum canis complex
IMA Fungus, Volume 14, No. 1, Article 14, Year 2023
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Description
The Microsporum canis complex consists of one zoophilic species, M. canis, and two anthropophilic species, M. audouinii and M. ferrugineum. These species are the most widespread zoonotic pathogens causing dermatophytosis in cats and humans worldwide. To clarify the evolutionary relationship between the three species and explore the potential host shift process, this study used phylogenetic analysis, population structure analysis, multispecies coalescent analyses, determination of MAT idiomorph distribution, sexual crosses, and macromorphology and physicochemical features to address the above questions. The complex of Microsporum canis, M. audouinii and M. ferrugineum comprises 12 genotypes. MAT1-1 was present only in M. canis, while the anthropophilic entities contained MAT1-2. The pseudocleistothecia were yielded by the mating behaviour of M. canis and M. audouinii. Growth rates and lipase, keratinolysis and urea hydrolytic capacities of zoophilic M. canis isolates were all higher than those of anthropophilic strains; DNase activity of M. ferrugineum exceeded that of M. canis. The optimum growth temperature was 28 °C, but 22 °C favoured the development of macroconidia. Molecular data, physicochemical properties and phenotypes suggest the adaptation of zoophilic M. canis to anthropophilic M. ferrugineum, with M. audouinii in an intermediate position. © 2023, The Author(s).
Authors & Co-Authors
Ahmed, Sarah A.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Netherlands, Hilversum
Foundation Atlas of Clinical Fungi
Uhrlass, Silke
Germany, Mölbis
Labor Für Medizinische Mikrobiologie
Cafarchia, Claudia
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Hayette, Marie Pierre
Belgium, Liege
Centre Hospitalier Universitaire de Liege
Sacheli, Rosalie
Belgium, Liege
Centre Hospitalier Universitaire de Liege
Kang, Yingqian
China, Beijing
Ministry of Education of the People's Republic of China
China, Guiyang
Guizhou Academy of Tobacco Science
de Hoog, Gerrits Sybren
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Netherlands, Hilversum
Foundation Atlas of Clinical Fungi
Brazil, Curitiba
Universidade Federal do Parana
China, Beijing
Ministry of Education of the People's Republic of China
Feng, Peiying
Unknown Affiliation
Statistics
Citations: 1
Authors: 8
Affiliations: 11
Identifiers
Doi:
10.1186/s43008-023-00120-x
ISSN:
22106340
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study