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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Anemia in human immunodeficiency virus-infected and uninfected women in Rwanda
American Journal of Tropical Medicine and Hygiene, Volume 84, No. 3, Year 2011
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Description
To determine the prevalence and risk factors of anemia among human immunodeficiency virus (HIV) - infected women in Rwanda and the influence of highly active antiretroviral therapy (HAART) on anemia, we analyzed 200 HIV-positive women and 50 HIV-negative women in a cross-sectional study. Clinical examinations and iron and vitamin B12 assays were performed, and complete blood counts, serum folic acid levels, and CD4 cell count determined. The prevalence of anemia was significantly higher among HIV-positive women (29%) than among HIV-negative women (8%) (P < 0.001). Risk factors for anemia were lower body mass index (odds ratio [OR] = 3.4, 95% confidence interval [CI] = 2.4-4.1), zidovudine use (OR = 1.14, 95% CI = 1.01-1.29), lack of HAART (OR = 1.44, 95% CI = 1.21-1.67), oral candidiasis (OR = 1.4, 95% CI = 1.2-1.6), pulmonary tuberculosis (OR = 1.8, 95% CI = 1.7-2.2), cryptococcal meningitis (OR = 1.6, 95% CI = 1.21-1.8), Pneumocystis jiroveci pneumonia (OR = 1.41, 95% CI = 1.20-1.65) and CD4 lymphocyte count < 200 cells/μL (OR = 2.41, 95% CI = 2.01-3.07). The mean ± SD hemoglobin level of 10.9 ± 1.6 g/dL at HAART initiation significantly increased to 12.3 ± 1.5 g/dL in 8 months (P < 0.001). Anemia increases with HIV stage, and HAART is associated with a significant improvement in hemoglobin levels. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Masaisa, Florence
Rwanda, Butare
University of Rwanda
Gahutu, Jean Bosco
Rwanda, Butare
University of Rwanda
Mukiibi, Joshua M.
Rwanda, Butare
University of Rwanda
Delanghe, Joris Richard
Belgium, Ghent
Universiteit Gent
Belgium, Ghent
Universitair Ziekenhuis Gent
Philippe, J. J.
Belgium, Ghent
Universiteit Gent
Belgium, Ghent
Universitair Ziekenhuis Gent
Statistics
Citations: 63
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2011.10-0519
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Rwanda
Participants Gender
Female