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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt
Journal of Viral Hepatitis, Volume 22, No. 3, Year 2015
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Description
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to assess liver fibrosis in chronic hepatitis C (CHC) and is required to decide whether a treatment should be proposed. Many of its disadvantages have led to develop noninvasive methods to replace LB. These new methods should be evaluated in Egypt, where circulating virus genotype 4 (G4), increased body mass index and co-infection with schistosomiasis may interfere with liver fibrosis assessment. Egyptian CHC-infected patients with G4 underwent a LB, an elastometry measurement (Fibroscan©), and serum markers (APRI, Fib4 and Fibrotest©). Patients had to have a LB ≥15 mm length or ≥10 portal tracts with two pathologists blinded readings to be included in the analysis. Patients with hepatitis B virus co-infection were excluded. Three hundred and twelve patients are reported. The performance of each technique for distinguishing F0F1 vs F2F3F4 was compared. The area under receiver operating characteristic curves was 0.70, 0.76, 0.71 and 0.75 for APRI, Fib-4, Fibrotest© and Fibroscan©, respectively (no influence of schistosomiasis was noticed). An algorithm using the Fib4 for identifying patients with F2 stage or more reduced by nearly 90% the number of liver biopsies. Our results demonstrated that noninvasive techniques were feasible in Egypt, for CHC G4-infected patients. Because of its validity and its easiness to perform, we believe that Fib4 may be used to assess the F2 threshold, which decides whether treatment should be proposed or delayed.
Authors & Co-Authors
Bonnard, P.
France, Paris
Hôpital Tenon
France, Paris
Inserm
Elsharkawy, Aisha
Egypt, Cairo
Faculty of Medicine
Zalata, Khaled Refaat
Egypt, Mansoura
Faculty of Medicine
Delarocque-Astagneau, Elisabeth
France, Paris
Institut Pasteur, Paris
Biard, Lucie
France, Paris
Institut Pasteur, Paris
Le-Fouler, Lénaïg
France, Paris
Institut Pasteur, Paris
Hassan, A. B.
Egypt, Cairo
Faculty of Medicine
Abdel-Hamid, Mohamed A.
Egypt, Minya
Faculty of Medicine
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
El-Daly, Maï Mohamed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Gamal, Mahmoud E.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
El-Kassas, Mohamed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Bédossa, Pierre
France, Clichy
Hôpital Beaujon
Carrat, Fabrice
France, Paris
Inserm
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
France, Paris
Conservatoire National Des Arts et Metiers
Esmat, Gamal
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Statistics
Citations: 43
Authors: 15
Affiliations: 9
Identifiers
Doi:
10.1111/jvh.12285
ISSN:
13520504
e-ISSN:
13652893
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Egypt