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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in diagnosing metastasis to the pancreas: A tertiary center experience
Pancreatology, Volume 11, No. 4, Year 2011
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Description
Background: Metastasis to the pancreas (MP) is a rare entity that is difficult to identify by imaging alone. Few reports have described endoscopic ultrasound (EUS) and EUS-guided fine-needle aspiration (FNA) findings. Herein, we try to describe the EUS and EUS-FNA characteristics of MP. Methods: This retrospective study compared 28 patients with MP (13 males; mean age: 60.1 ± 12.6 years) and 60 control patients (30 males; 62.7 ± 11.5 years) with pancreatic ductal adenocarcinoma (PDAC). All lesions were characterized by EUS, and MP was diagnosed by EUS-FNA (n = 16), surgery (n = 6) or both (n = 6). Results: Multivariate logistic regres- sion revealed that the presence of regular borders (p = 0.004; OR: 8.81, 95% CI: 1.97-39.4), the absence of retention cysts (p = 0.045; OR: 12.5, 95% CI: 1.06-147.0), and the absence of main pancreatic duct (MPD) dilation (p = 0.003; OR: 8.18, 95% CI: 2.04-32.8) were predictors of MP rather than PDAC. The EUS-FNA sampling adequacy was 95.4% (21/22), and the correct diagnosis was obtained in 95.2% (20/21) of cases when K-ras mutation analysis and/or immunostaining were added. Conclusion: The presence of regular borders, the absence of retention cysts and the presence of nondilated MPD on EUS indicate MP rather than PDAC. This diagnosis can be accurately confirmed by EUS-FNA with immunostaining and/or K-ras analysis. Copyright © 2011 S. Karger AG, Basel and IAP.
Authors & Co-Authors
Hijioka, Susumu
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Matsuo, Keitaro
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Mizuno, Nobumasa
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Hara, Kazuo
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Mekky, M. A.
Egypt, Asyut
Faculty of Medicine
Bhatia, Vikram K.
India, New Delhi
Institute of Liver and Biliary Sciences
Hosoda, Waki
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Yatabe, Yasushi
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Shimizu, Yashuhiro
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Kondo, Shinya
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Tajika, Masahiro
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Niwa, Yasumasa
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Tamada, Kiichi
Japan, Kawachi District
Jichi Medical University
Yamao, Kenji
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Statistics
Citations: 30
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1159/000330536
ISSN:
14243903
e-ISSN:
14243911
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study