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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
MCP1 SNPS and pulmonary tuberculosis in cohorts from west africa, the USA and argentina: Lack of association or epistasis with IL12B polymorphisms
PLoS ONE, Volume 7, No. 2, Article e32275, Year 2012
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Description
The monocyte chemotactic protein-1 (MCP-1) is a chemokine that plays an important role in the recruitment of monocytes to M. tuberculosis infection sites, and previous studies have reported that genetic variants in MCP1 are associated with differential susceptibility to pulmonary tuberculosis (PTB). We examined eight MCP1 single nucleotide polymorphisms (SNPs) in a multi-ethnic, case-control design that included: 321 cases and 346 controls from Guinea-Bissau, 258 cases and 271 controls from The Gambia, 295 cases and 179 controls from the U.S. (African-Americans), and an additional set of 237 cases and 144 controls of European ancestry from the U.S. and Argentina. Two locus interactions were also examined for polymorphisms in MCP1 and interleukin 12B (IL12B), another gene implicated in PTB risk. Examination of previously associated MCP1 SNPs rs1024611 (-2581A/G), rs2857656 (-362G/C) and rs4586 (+900C/T) did not show evidence for association. One interaction between rs2857656 and IL12B SNP rs2288831 was observed among Africans but the effect was in the opposite direction in Guineans (OR = 1.90, p = 0.001) and Gambians (OR = 0.64, p = 0.024). Our data indicate that the effect of genetic variation within MCP1 is not clear cut and additional studies will be needed to elucidate its role in TB susceptibility. © 2012 Velez Edwards et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3288089/bin/pone.0032275.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3288089/bin/pone.0032275.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3288089/bin/pone.0032275.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3288089/bin/pone.0032275.s004.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3288089/bin/pone.0032275.s005.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3288089/bin/pone.0032275.s006.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3288089/bin/pone.0032275.s007.doc
Authors & Co-Authors
Edwards, Digna R.Velez
Unknown Affiliation
Tacconelli, Alessandra
Unknown Affiliation
Wejse, Christian
Unknown Affiliation
Hill, Philip C.
Unknown Affiliation
Morris, Gerard A.J.
Unknown Affiliation
Edwards, Todd L.
Unknown Affiliation
Gilbert, John R.
Unknown Affiliation
Myers, Jamie L.
Unknown Affiliation
Park, Yo Son
Unknown Affiliation
Stryjewski, Martín E.
Unknown Affiliation
Abbate, Eduardo H.
Unknown Affiliation
Estevan, Rosa
Unknown Affiliation
Rabna, Paulo
Unknown Affiliation
Novelli, Giuseppe
Unknown Affiliation
Hamilton, Carol Dukes
Unknown Affiliation
Adegbola, Richard A.
Unknown Affiliation
Østergaard, Lars Jørgen
Unknown Affiliation
Williams, Scott M.
Unknown Affiliation
Scott, William K.
Unknown Affiliation
Sirugo, G.
Unknown Affiliation
Statistics
Citations: 20
Authors: 20
Affiliations: 15
Identifiers
Doi:
10.1371/journal.pone.0032275
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Case-Control Study
Study Locations
Multi-countries
Gambia
Guinea
Guinea-Bissau