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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic
Journal of Medical Virology, Volume 87, No. 6, Year 2015
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Description
Zaire Ebola virus (EBOV) is an enveloped non-segmented negative strand RNA virus of 19kb in length belonging to the family Filoviridae. The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred in the forested areas of south eastern Guinea, that began in February 2014 and is still ongoing. The recent Ebola outbreak, is affecting other countries in West Africa, in addiction to Guinea: Liberia, Nigeria, and Sierra Leone. In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation. © 2015 Wiley Periodicals, Inc.
Authors & Co-Authors
Giovanetti, Marta
Italy, Rome
Istituto Superiore Di Sanita
Grifoni, Alba
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Lo Presti, Alessandra
Italy, Rome
Istituto Superiore Di Sanita
Cella, Eleonora
Italy, Rome
Istituto Superiore Di Sanita
Montesano, C.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Zehender, Gianguglielmo
Italy, Milan
Università Degli Studi Di Milano
Colizzi, Vittorio C.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Amicosante, Massimo
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Bulgaria, Sofia
Proxagen Ltd.
Ciccozzi, M.
Italy, Rome
Istituto Superiore Di Sanita
Italy, Rome
University Hospital Campus Bio-medico
Statistics
Citations: 6
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1002/jmv.24133
ISSN:
01466615
Research Areas
Genetics And Genomics
Infectious Diseases
Substance Abuse
Study Locations
Multi-countries
Guinea
Liberia
Nigeria
Sierra Leone