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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Development of Irritable Bowel Syndrome Features Over a 5-year Period
Clinical Gastroenterology and Hepatology, Volume 16, No. 8, Year 2018
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Description
Background & Aims: There are few data from longitudinal studies of the gastrointestinal and psychologic features of irritable bowel syndrome (IBS). We studied within-person correlations among features of IBS, along with progression of gastrointestinal (GI) symptoms and quality of life, and factors associated with changes over time. Methods: We performed a longitudinal study of 276 patients with IBS in Sweden (70% female; ages, 19–76 years) who completed questionnaires, each year for 5 years, about their GI symptom severity, quality of life, GI-specific anxiety, general anxiety, depression, and coping resources. We performed within-person correlation analyses, latent class growth analysis, and random-intercept cross-lagged panel analysis. Results: Within-person correlations with GI symptom severity were strongest for quality of life (r = –0.56) and GI-specific anxiety (r = 0.47). Progression of GI symptom severity was defined based on 3 classes; the class with the highest mean levels of GI, depression, and (GI-specific) anxiety symptoms at baseline did not improve over the 5-year period, contrary to the other classes. GI-specific anxiety was associated with an increase in GI symptom severity and decrease in quality of life 1 year later (P <.05) but other features of IBS were not. Conclusions: In a 5-year study of patients with IBS in Sweden, we found 3 classes of GI symptom development. We found levels of GI-specific anxiety to associate with GI symptom severity and quality of life 1 year later. Clinicians should be aware of GI-specific anxiety in patients with IBS, to identify patients at risk for lack of long-term symptom improvement with standard medical treatment. © 2018 AGA Institute
Authors & Co-Authors
Clevers, Egbert
Belgium, Leuven
Ku Leuven
Sweden, Gothenburg
Göteborgs Universitet
Tack, Jan F.
Belgium, Leuven
Ku Leuven
Luyckx, Koen
Belgium, Leuven
Ku Leuven
Simrén, Magnus
Sweden, Gothenburg
Göteborgs Universitet
United States, Chapel Hill
The University of North Carolina at Chapel Hill
van Oudenhove, Lukas
Belgium, Leuven
Ku Leuven
Statistics
Citations: 18
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.cgh.2018.02.043
ISSN:
15423565
Research Areas
Disability
Mental Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female