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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
South African GB virus C isolates: Interactions between genotypes 1 and 5 isolates and HIV
Journal of Infectious Diseases, Volume 192, No. 12, Year 2005
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Description
GB virus C (GBV-C) is a common, apparently nonpathogenic human flavivirus that has been associated in some studies with prolonged survival in human immunodeficiency virus (HIV)-positive persons. There are 5 distinct GBV-C genotypes localized to specific geographic regions, and genotype 2 has been previously shown to inhibit HIV replication in vitro in lymphocyte cultures. We identified GBV-C virus isolates representing genotypes 1, 2, and 5 in samples from South African blood donors. GBV-C genotype 1 and 5 isolates replicated in lymphocyte culture, inhibited X4 and R5 HIV-1 isolates, and induced RANTES and stromal-derived factor-1 chemokines in vitro. Thus, African GBV-C genotypes can inhibit HIV replication in vitro. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Xiang, Jinhua
United States, Iowa City
University of Iowa
Sathar, Mahomed Aslam
South Africa, Durban
The Nelson R. Mandela Medical School
McLinden, James H.
United States, Iowa City
University of Iowa
Klinzman, Donna Vaness
United States, Iowa City
University of Iowa
Chang, Qing
United States, Iowa City
University of Iowa
Stapleton, Jack T.
United States, Iowa City
University of Iowa
Statistics
Citations: 25
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1086/498170
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases