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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Characteristics of patients with atrial fibrillation prescribed antiplatelet monotherapy compared with those on anticoagulants: Insights from the GARFIELD-AF registry
European Heart Journal, Volume 39, No. 6, Year 2018
Notification
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Description
Aims Current atrial fibrillation (AF) guidelines discourage antiplatelet (AP) monotherapy as alternative to anticoagulants (ACs). Why AP only is still used is largely unknown. Methods and results Factors associated with AP monotherapy prescription were analysed in GARFIELD-AF, a registry of patients with newly diagnosed (6 weeks) AF and 1 investigator-determined stroke risk factor. We analysed 51 270 patients from 35 countries enrolled into five sequential cohorts between 2010 and 2016. Overall, 20.7% of patients received AP monotherapy, 52.1% AC monotherapy, and 14.1% AP AC. Most AP monotherapy (82.5%) and AC monotherapy (86.8%) patients were CHA2DS2-VASc 2. Compared with patients on AC monotherapy, AP monotherapy patients were frequently Chinese (vs. Caucasian, odds ratio 2.73) and more likely to have persistent AF (1.32), history of coronary artery disease (2.41) or other vascular disease (1.67), bleeding (2.11), or dementia (1.81). The odds for AP monotherapy increased with 5 years of age increments for patients 75 years (1.24) but decreased with age increments for patients 55-75 years (0.86). Antiplatelet monotherapy patients were less likely to have paroxysmal (0.67) or permanent AF (0.57), history of embolism (0.56), or alcohol use (0.90). With each cohort, AP monotherapy declined (P 0.0001), especially non-indicated use. AP AC and no antithrombotic therapy were unchanged. However, even in 2015 and 2016, about 50% of AP-Treated patients had no indication except AF (71% were CHA2DS2-VASc 2). Conclusion Prescribing AP monotherapy in newly diagnosed AF has declined, but even nowadays a substantial proportion of AP-Treated patients with AF have no indication for AP. All rights reserved. © The Author 2017.
Authors & Co-Authors
Verheugt, Freek W.Aa
Netherlands, Amsterdam
Olvg
Gao, Haiyan
United Kingdom, London
Thrombosis Research Institute
Al-Mahmeed, Wael Abdulrahman R.
United Arab Emirates, Abu Dhabi
Cleveland Clinic Abu Dhabi
Ambrosio, G. B.
Italy, Perugia
Università Degli Studi Di Perugia
Angchaisuksiri, Pantep
Thailand, Nakhon Pathom
Mahidol University
Atar, Dan
Norway, Oslo
Universitetet I Oslo
Bassand, Jean Pierre L.
United Kingdom, London
Thrombosis Research Institute
France, Besancon
Université de Franche-comté
Camm, Alan John
United Kingdom, London
St George’s, University of London
Cools, Frank Johan C.
Belgium, Brasschaat
Algemeen Ziekenhuis Klina
Eikelboom, John W.
Canada, Hamilton
Population Health Research Institute, Ontario
Kayani, Gloria
United Kingdom, London
Thrombosis Research Institute
Lim, Toon Wei
Singapore, Singapore City
National University Hospital
Misselwitz, Frank
Germany, Berlin
Bayer Pharma ag
Pieper, Karen S.
United States, Durham
Duke Clinical Research Institute
van Eickels, Martin
Germany, Leverkusen
Bayer ag
Kakkar, Ajay K.
United Kingdom, London
Thrombosis Research Institute
United Kingdom, London
University College London
Fitzmaurice, David Andrew
Unknown Affiliation
Goldhaber, Samuel Zachary
Unknown Affiliation
Goto, Shinya
Unknown Affiliation
Haas, Sylvia K.
Unknown Affiliation
Hacke, Werner
Unknown Affiliation
Mantovani, Lorenzo G.
Unknown Affiliation
Turpie, Alexander G.G.
Unknown Affiliation
Fox, Keith A.A.
Unknown Affiliation
Gersh, Bernard John
Unknown Affiliation
Luciardi, Héctor Lucas
Unknown Affiliation
Gibbs, Harry H.
Unknown Affiliation
Brodmann, Marianne
Unknown Affiliation
Barretto, Antoniò Carlos Pereira
Unknown Affiliation
Connolly, Stuart J.
Unknown Affiliation
Spyropoulos, Alex C.
Unknown Affiliation
Corbalàn, Ramõn L.
Unknown Affiliation
Hu, Dayi
Unknown Affiliation
Janský, Petr
Unknown Affiliation
Nielsen, Jørn Dalsgaard
Unknown Affiliation
Ragy, Hany Ibrahim
Unknown Affiliation
Raatikainen, Pekka
Unknown Affiliation
Le-Heuzey, Jean Yves F.
Unknown Affiliation
Darius, Harald
Unknown Affiliation
Keltai, Mátyás
Unknown Affiliation
Kakkar, Sanjay
Unknown Affiliation
Sawhney, Jitendra Pal Singh
Unknown Affiliation
Agnelli, Giancarlo
Unknown Affiliation
Koretsune, Yukihiro
Unknown Affiliation
Díaz, Carlos Jerjes Sánchez Jesus Jaime Illescas
Unknown Affiliation
Ten Cate, Hugo
Unknown Affiliation
Stȩpiñska, Janina
Unknown Affiliation
Panchenko, Elizaveta P.
Unknown Affiliation
Jacobson, Barry Frank
Unknown Affiliation
Oh, Seil
Unknown Affiliation
Viñolas, Xavier
Unknown Affiliation
Rosenqvist, Mårten
Unknown Affiliation
Steffel, Jan
Unknown Affiliation
Chen, K. N.
Unknown Affiliation
Zhao, Yusheng
Unknown Affiliation
Zhang, Huaiqin
Unknown Affiliation
Chen, J. Z.
Unknown Affiliation
Cao, Shiping
Unknown Affiliation
Wang, Daowen
Unknown Affiliation
Yang, Yuejin
Unknown Affiliation
Li, Weihua
Unknown Affiliation
Yin, Yuehui
Unknown Affiliation
Tao, Guizhou
Unknown Affiliation
Yang, Ping
Unknown Affiliation
Chen, Yingmin
Unknown Affiliation
He, Shenghu
Unknown Affiliation
Wang, Ying
Unknown Affiliation
Wang, Yong
Unknown Affiliation
Fu, Guosheng
Unknown Affiliation
Li, Xin
Unknown Affiliation
Wu, Tongguo
Unknown Affiliation
Cheng, Xiaoshu
Unknown Affiliation
Yan, Xiaowei
Unknown Affiliation
Zhao, Ruiping
Unknown Affiliation
Chen, Moshui
Unknown Affiliation
Xiong, Longgen
Unknown Affiliation
Chen, Ping
Unknown Affiliation
Jiao, Yang
Unknown Affiliation
Guo, Ying
Unknown Affiliation
Xue, Li
Unknown Affiliation
Wang, F. Z.
Unknown Affiliation
Li, Hao
Unknown Affiliation
Yang, Zhiming
Unknown Affiliation
Bai, C. L.
Unknown Affiliation
Chen, J.
Unknown Affiliation
Chen, J. Y.
Unknown Affiliation
Chen, Xinyue
Unknown Affiliation
Feng, Shaodan
Unknown Affiliation
Fu, Q. H.
Unknown Affiliation
Gao, X. J.
Unknown Affiliation
Guo, W. N.
Unknown Affiliation
He, Ronghua
Unknown Affiliation
He, X. A.
Unknown Affiliation
Hu, X. S.
Unknown Affiliation
Huang, X. F.
Unknown Affiliation
Li, Jennifer S.
Unknown Affiliation
Li, Lei
Unknown Affiliation
Li, Ya Huei
Unknown Affiliation
Liu, Tingting
Unknown Affiliation
Liu, Wenling
Unknown Affiliation
Liu, Yanyun
Unknown Affiliation
Lu, Z. C.
Unknown Affiliation
Jadhav, P.
Unknown Affiliation
Durgaprasad, Rajashekhar
Unknown Affiliation
Ravi Shankar, A. G.
Unknown Affiliation
Rajput, Rajeeve Kumar
Unknown Affiliation
Bhargava, Kartikeya
Unknown Affiliation
Sarma, R.
Unknown Affiliation
Srinivas, Arun
Unknown Affiliation
Roy, Debabrata
Unknown Affiliation
Nagamalesh, Udigala Madappa
Unknown Affiliation
Chopda, Manoj
Unknown Affiliation
Kishore, Ravi
Unknown Affiliation
Kulkarni, Govind
Unknown Affiliation
Chandwani, Prakash
Unknown Affiliation
Pothiwala, Rasesh Atulbhai
Unknown Affiliation
Shah, Sahrish H.
Unknown Affiliation
Vijan, Vinod Madan
Unknown Affiliation
Bantwal, Ganapathi
Unknown Affiliation
Sharma, Mukul K.
Unknown Affiliation
Higa, Satoshi
Unknown Affiliation
Watanabe, Hiroshi
Unknown Affiliation
Lim, Wendy T.
Unknown Affiliation
Kim, Jae-hyung
Unknown Affiliation
Cho, Myeong-chan
Unknown Affiliation
Nam, Gi-byoung
Unknown Affiliation
On, Young-keun
Unknown Affiliation
Lim, Hongeuy
Unknown Affiliation
Kim, Kee-sik
Unknown Affiliation
Kim, Chongjin
Unknown Affiliation
Phrommintikul, A.
Unknown Affiliation
Sawanyawisuth, Kittisak
Unknown Affiliation
Yilmaz, Mehmet Birhan
Unknown Affiliation
Öngen, Zeki
Unknown Affiliation
Yorgun, Hikmet
Unknown Affiliation
Ersanlı, Murat Kazım
Unknown Affiliation
Caliskan, S.
Unknown Affiliation
Yetis Sayin, Begüm
Unknown Affiliation
Vensentini, Natalia
Unknown Affiliation
Ingaramo, Adrián C.
Unknown Affiliation
Zapata, Gerardo O.
Unknown Affiliation
Dran, Ricardo Dario
Unknown Affiliation
Fernández, Alberto Alfredo
Unknown Affiliation
Cartasegna, Luis Rodolfo
Unknown Affiliation
Berli, M. A.
Unknown Affiliation
Vilamajó, Oscar A.Gomez
Unknown Affiliation
Costabel, Juan Pablo
Unknown Affiliation
Costamagna, Osvaldo J.A.
Unknown Affiliation
Gurfinkel, Enrique P.
Unknown Affiliation
Hrabar, Adrián D.
Unknown Affiliation
Maffei, Laura Elena
Unknown Affiliation
Novas, V.
Unknown Affiliation
Rodríguez, Manuel A.
Unknown Affiliation
Schygiel, Pablo Omar
Unknown Affiliation
Teixeira, Marcelo Silveira
Unknown Affiliation
Lópes, Renato Deláscio
Unknown Affiliation
Manenti, Euler Roberto Fernandes
Unknown Affiliation
Saraiva, José Francisco Kerr
Unknown Affiliation
Précoma, Dalton Bertolim
Unknown Affiliation
Reis, Gilmar
Unknown Affiliation
Botelho, Roberto Vieira
Unknown Affiliation
Maia, Lília Nigro
Unknown Affiliation
Fonseca, Cândida
Unknown Affiliation
Lopes, Demetrius Klee
Unknown Affiliation
Santos, Marlene S.
Unknown Affiliation
Armaganijan, Luciana Vidal
Unknown Affiliation
Herrera, Carlos Hernández
Unknown Affiliation
Drexel, Heinz
Unknown Affiliation
Podczeck-Schweighofer, Andrea
Unknown Affiliation
Huber, Kurt
Unknown Affiliation
Lang, Wielfried
Unknown Affiliation
Pichler, Martin
Unknown Affiliation
Strohmer, Bernhard
Unknown Affiliation
Said, Ahmad
Unknown Affiliation
Vogel, Birgit
Unknown Affiliation
Mairesse, Georges H.
Unknown Affiliation
Heyse, Alex M.
Unknown Affiliation
Statistics
Citations: 31
Authors: 177
Affiliations: 15
Identifiers
Doi:
10.1093/eurheartj/ehx730
ISSN:
0195668X
Research Areas
Mental Health
Noncommunicable Diseases
Substance Abuse
Study Design
Cohort Study
Case-Control Study