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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Emergence of the silicon human and network targeting drugs
European Journal of Pharmaceutical Sciences, Volume 46, No. 4, Year 2012
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Description
The development of disease may be characterized as a pathological shift of homeostasis; the main goal of contemporary drug treatment is, therefore, to return the pathological homeostasis back to the normal physiological range. From the view point of systems biology, homeostasis emerges from the interactions within the network of biomolecules (e.g. DNA, mRNA, proteins), and, hence, understanding how drugs impact upon the entire network should improve their efficacy at returning the network (body) to physiological homeostasis. Large, mechanism-based computer models, such as the anticipated human whole body models (silicon or virtual human), may help in the development of such network-targeting drugs. Using the philosophical concept of weak and strong emergence, we shall here take a more general look at the paradigm of network-targeting drugs, and propose our approaches to scale the strength of strong emergence. We apply these approaches to several biological examples and demonstrate their utility to reveal principles of bio-modeling. We discuss this in the perspective of building the silicon human. © 2011 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Kolodkin, Alexey
Unknown Affiliation
Boogerd, Fred C.
Unknown Affiliation
Plant, Nick J.
Unknown Affiliation
Bruggeman, Frank J.
Unknown Affiliation
Goncharuk, Valeri
Unknown Affiliation
Lunshof, Jeantine E.
Unknown Affiliation
Moreno-Sánchez, Rafael
Unknown Affiliation
Yilmaz, Nilgun
Unknown Affiliation
Bakker, Barbara Marleen
Unknown Affiliation
Snoep, Jacky L.
Unknown Affiliation
Balling, Rudi
Unknown Affiliation
Westerhoff, Hans Westerhoff V.
Unknown Affiliation
Statistics
Citations: 38
Authors: 12
Affiliations: 15
Identifiers
Doi:
10.1016/j.ejps.2011.06.006
ISSN:
09280987
Research Areas
Genetics And Genomics