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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis
Arthritis Research and Therapy, Volume 15, No. 5, Article R152, Year 2013
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Description
Introduction: Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals. In this study we evaluated the potential association of this gene polymorphism with subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in RA patients. Methods: This study included 502 RA patients from Northern Spain. The ZC3HC1 rs11556924 polymorphism was genotyped with TaqMan single-nucleotide polymorphism (SNP) genotyping assays (C__31283062_10) in a 7900HT real-time polymerase chain reaction (PCR) system. cIMT was also assessed in these patients by carotid ultrasonography (US) technology. Results:RA patients carrying the TT genotype had significantly higher cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.76 ± 0.18 mm and mean ± SD: 0.71 ± 0.16 mm respectively; P = 0.03) even after adjusting the results for sex, age at the time of US study, follow-up time and traditional CV risk factors (P = 0.04) evidencing that the effect conferred by ZC3HC1 rs11556924 polymorphism is independent of the traditional CV risk factors.Conclusion: Our results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in RA. © 2013 López-Mejías et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
López-Mejías, Raquel
Unknown Affiliation
Genre, Fernanda
Unknown Affiliation
Bermúdez, Mercedes G.
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Corrales, Alfonso F.
Unknown Affiliation
González-Juanatey, Carlos
Spain, Lugo
Hospital Lucus Augusti
Llorca-Díaz, Javier Francisco
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Miranda-Filloy, José Alberto
Spain, Lugo
Hospital Lucus Augusti
Rueda-Gotor, Javier
Unknown Affiliation
Blanco-Alonso, Ricardo
Unknown Affiliation
Castañeda, Santos
Spain, Madrid
Hospital Universitario de la Princesa
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
González-Gay, Miguel Ángel
Unknown Affiliation
Statistics
Citations: 34
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1186/ar4335
ISSN:
14786362
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Systematic review