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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Clinic-based surveillance for bacterial- and rotavirus-associated diarrhea in Egyptian children
American Journal of Tropical Medicine and Hygiene, Volume 74, No. 1, Year 2006
Notification
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Description
To identify enteropathogens for vaccine development, we implemented clinic-based surveillance for severe pediatric diarrhea in Egypt's Nile River Delta. Over 2 years, a physician clinically evaluated and obtained stool samples for microbiology from patients with diarrhea and less than 6 years of age. In the first (N = 714) and second clinic (N = 561), respectively, 36% (N = 254) and 46% (N = 260) of children were infected with rotavirus, enterotoxigenic Escherichia coli (ETEC), Campylobacter, or Shigella. When excluding mixed rotavirus-bacterial infections, for the first and second clinic, 23% and 10% had rotavirus-associated diarrhea, and 14% and 17% had ETEC-associated diarrhea, respectively. Campylobacter-associated diarrhea was 1% and 3%, and Shigella-associated diarrhea was 2% and 1%, respectively, for the two clinics. Rotavirus-associated diarrhea peaked in late summer to early winter, while bacterial agents were prevalent during summer. Rotavirus-associated cases presented with dehydration, vomiting, and were often hospitalized. Children with Shigella- or Campylobacter-associated diarrhea reported as watery diarrhea and rarely dysentery. ETEC did not have any clinically distinct characteristics. For vaccine development and/or deployment, our study suggests that rotavirus is of principle concern, followed by ETEC, Shigella, and Campylobacter. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Wierzba, Thomas F.
Unknown Affiliation
Abdel-Messih, Ibrahim Adib
United States, New York
Us Naval Medical Research Unit No. 3
Abu-Elyazeed, Remon R.
Unknown Affiliation
Putnam, Shannon D.
United States, New York
U.s. Nav. Med. Research Unit No. 2
Kamal, Karim
United States, New York
Us Naval Medical Research Unit No. 3
Rozmajzl, Patrick J.
United States, Silver Spring
Naval Medical Research Center
Ahmed, Salwa Fouad
United States, New York
Us Naval Medical Research Unit No. 3
Fatah, Abdel
Egypt, Benha
Benha Fever Hospital
Zabedy, Khaled
Egypt
Abu Homos District Hospital
Shaheen, Hind Ibrahim
United States, New York
Us Naval Medical Research Unit No. 3
Sanders, John Walton
United States, New York
Us Naval Medical Research Unit No. 3
Frenck, Robert W.
United States, New York
Us Naval Medical Research Unit No. 3
Statistics
Citations: 71
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2006.74.148
ISSN:
00029637
Research Areas
Health System And Policy
Maternal And Child Health
Study Locations
Egypt