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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Low avidity of human papillomavirus (HPV) type 16 antibodies is associated with increased risk of low-risk but not high-risk HPV type prevalence
BMC Research Notes, Volume 4, Article 170, Year 2011
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Description
Background: Low avidity of antibodies against viral, bacterial and parasitic agents has been used for differential diagnosis of acute versus recent/past infections. The low-avidity antibodies may however, persist for a longer period in some individuals. Findings. We studied the association of human papillomavirus (HPV) type 16 antibody avidity with seroprevalence to HPV types 6/11/18/31/33/45. Antibody avidity was analysed for 365 HPV16 seropositive pregnant Finnish and Ugandan women using a modified ELISA. Low avidity of HPV16 antibodies was found in 15% of Finnish and 26% of Ugandan women. Ugandan women with low-avidity HPV16 antibodies had an increased risk estimate for HPV6/11 (odds ratio, OR 2.9; 95%CI 1.01-8.4) seropositivity but not to high-risk HPV types 18/31/33/45. Conclusion: Association of the low avidity HPV16 antibody "phenotype" with possible susceptibility to infections with other HPV types warrants investigation. © 2011 Namujju et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Namujju, Proscovia Bazanya
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Uganda, Entebbe
Uganda Virus Research Institute
Finland, Tampere
Tampere University
Hedman, Lea
Finland, Helsinki
Helsingin Yliopisto
Hedman, K.
Finland, Helsinki
Helsingin Yliopisto
Banura, Cecily
Uganda, Kampala
Makerere University
Mbidde, Edward Katongole
Uganda, Entebbe
Uganda Virus Research Institute
Kizito, Dennison
Uganda, Entebbe
Uganda Virus Research Institute
Byaruhanga, Romano Nkumbwa B.
Uganda
San Raphael of St. Francis Hospital
Sweden, Stockholm
Karolinska Institutet
Muwanga, Moses
Uganda
Entebbe Hospital
Kirnbauer, Reinhard
Austria, Vienna
Medizinische Universität Wien Universitätsklinik Für Dermatologie
Surcel, Heljä Marja
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Lehtinen, Matti O.
Finland, Tampere
Tampere University
Statistics
Citations: 12
Authors: 11
Affiliations: 9
Identifiers
Doi:
10.1186/1756-0500-4-170
Research Areas
Cancer
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Female