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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Acupuncture for ovulation induction in polycystic ovary syndrome: A randomized controlled trial
American Journal of Physiology - Endocrinology and Metabolism, Volume 304, No. 9, Year 2013
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Description
Acupuncture has been demonstrated to improve menstrual frequency and to decrease circulating testosterone in women with polycystic ovary syndrome (PCOS). Our aim was to investigate whether acupuncture affects ovulation frequency and to understand the underlying mechanisms of any such effect by analyzing LH and sex steroid secretion in women with PCOS. This prospective, randomized, controlled clinical trial was conducted between June 2009 and September 2010. Thirty-two women with PCOS were randomized to receive either acupuncture with manual and low-frequency electrical stimulation or to meetings with a physical therapist twice a week for 10-13 wk. Main outcome measures were changes in LH secretion patterns from baseline to after 10-13 wk of treatment and ovulation frequency during the treatment period. Secondary outcomes were changes in the secretion of sex steroids, anti-Müllerian hormone, inhibin B, and serum cortisol. Ovulation frequency during treatment was higher in the acupuncture group than in the control group. After 10-13 wk of intervention, circulating levels of estrone, estrone sulfate, estradiol, dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, free testosterone, dihydrotestosterone, androsterone glucuronide, androstane-3α,17β-diol-3-glucuronide, and androstane- 3α,17β-diol-17-glucuronide decreased within the acupuncture group and were significantly lower than in the control group for all of these except androstenedione. We conclude that repeated acupuncture treatments resulted in higher ovulation frequency in lean/overweight women with PCOS and were more effective than just meeting with the therapist. Ovarian and adrenal sex steroid serum levels were reduced with no effect on LH secretion. © 2013 the American Physiological Society.
Authors & Co-Authors
Johansson, Julia
Sweden, Gothenburg
Sahlgrenska Akademin
Redman, Leanne Maree
United States, Los Angeles
Pennington Biomedical Research Center
Veldhuis, Paula P.
United States, Charlottesville
University of Virginia
Sazonova, Antonina
Sweden, Gothenburg
Sahlgrenska Akademin
Labrie, Fernand
Canada, Quebec
Chu de Québec-université Laval
Saudi Arabia, Riyadh
Al-imam Muhammad Ibn Saud Islamic University
Holm, Göran
Sweden, Gothenburg
Sahlgrenska Akademin
Johannsson, Gudmundur F.
Sweden, Gothenburg
Sahlgrenska Akademin
Stener-Victorin, Elisabet
Sweden, Gothenburg
Sahlgrenska Akademin
China, Harbin
Heilongjiang University of Chinese Medicine
Statistics
Citations: 111
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1152/ajpendo.00039.2013
ISSN:
01931849
e-ISSN:
15221555
Research Areas
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Participants Gender
Female