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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Case-control study of risk factors for breast cancer in Nigerian women
International Journal of Cancer, Volume 119, No. 9, Year 2006
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Description
This study evaluated the potential risk factors for breast cancer in Nigerian women using a case-control design of 250 women with breast cancer and their age-matched female controls. Both cases and controls were recruited from 4 University Teaching Hospitals in Midwestern and Southeastern Nigeria. Data on the clinical and epidemiological characteristics were collected using interviewer-administered structured questionnaires. The mean age of the cases and controls were 46.1 and 47.1 years, respectively. Fifty-seven percent of the cases were premenopausal while 43% were post-menopausal. The association of risk factors with breast cancer was assessed using conditional logistic regression. Positive family history of breast cancer in first- and second-degree relatives (Odds ratio [OR] = 8.07, 95% confidence interval [CI], 1.003, 64.95, p = 0.04), education of high school level and above (OR = 1.35, 95% CI 1.04, 1.74, p = 0.0205), age at first fullterm pregnancy (FFTP) greater than 20 years (OR = 1.32 95% CI 1.01, 1.71, p = 0.0413) and waist/hip ratio (WHR) (OR = 1.98, 95% CI 1.27, 3.10, p = 0.0026) were associated with increased risk of breast cancer in the final multiple conditional logistic regression model. The findings from this study have shown that sociodemographic characteristics, reproductive variables and anthropometric measures are significant predictors of breast cancer risk in Nigerian women. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Okobia, Michael N.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Nigeria, Benin
University of Benin
Bunker, Clareann H.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Zmuda, Joseph M.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Kammerer, Candace
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Vogel, Victor
United States, Pittsburgh
University of Pittsburgh School of Medicine
Uche, Emmanuel E.
Nigeria, Port Harcourt
University of Port Harcourt
Anyanwu, Stanley Nnamdi Chinedu
Nigeria, Awka
Nnamdi Azikiwe University
Ezeome, Emmanuel R.
Nigeria, Naukka
University of Nigeria
Ferrell, Robert E.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Kuller, Lewis H.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Statistics
Citations: 66
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1002/ijc.22102
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Locations
Nigeria
Participants Gender
Female