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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
TNF-α and IL-6 affect human sperm function by elevating nitric oxide production
Reproductive BioMedicine Online, Volume 17, No. 5, Year 2008
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Description
Many studies have reported the effects of cytokines on human sperm function, even though their role and the mechanisms involved remain unclear. The effects of increasing concentrations of the cytokines TNF-α and IL-6 on human sperm motility and viability were assessed, and the possible mechanisms involved were investigated. TNF-α and IL-6 significantly reduced progressive motility at higher concentrations in a dose- and time-dependent manner. No differences were observed in cell viability. Both cytokines increased nitric oxide production in a dose-dependent manner. TNF-α and IL-6 did not statistically differ in their detrimental effects on human spermatozoa. These results indicate that TNF-α and IL-6 have an effect on sperm function. This effect is possibly mediated via an increase in nitric oxide production. © 2008 Published by Reproductive Healthcare Ltd.
Authors & Co-Authors
Lampiao, Fanuel
South Africa, Stellenbosch
Stellenbosch University
Du Plessis, Stefan Stephanus
South Africa, Stellenbosch
Stellenbosch University
Statistics
Citations: 69
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/S1472-6483(10)60309-4
ISSN:
14726483
Research Areas
Health System And Policy
Sexual And Reproductive Health