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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women
PLoS Neglected Tropical Diseases, Volume 10, No. 10, Article e0005009, Year 2016
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Description
P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few studies have examined their potential role as targets of immunity. We investigated the immunogenic properties of five VIR proteins and two long synthetic peptides containing conserved VIR sequences (PvLP1 and PvLP2) in the context of the PregVax cohort study including women from five malaria endemic countries: Brazil, Colombia, Guatemala, India and Papua New Guinea (PNG) at different timepoints during and after pregnancy. Antibody responses against all antigens were detected in all populations, with PNG women presenting the highest levels overall. P. vivax infection at sample collection time was positively associated with antibody levels against PvLP1 (fold-increase: 1.60 at recruitment -first antenatal visit-) and PvLP2 (fold-increase: 1.63 at delivery), and P. falciparum co-infection was found to increase those responses (for PvLP1 at recruitment, fold-increase: 2.25). Levels of IgG against two VIR proteins at delivery were associated with higher birth weight (27 g increase per duplicating antibody levels, p<0.05). Peripheral blood mononuclear cells from PNG uninfected pregnant women had significantly higher antigen-specific IFN-γ TH1 responses (p=0.006) and secreted less pro-inflammatory cytokines TNF and IL-6 after PvLP2 stimulation than P. vivax-infected women (p<0.05). These data demonstrate that VIR antigens induce the natural acquisition of antibody and T cell memory responses that might be important in immunity to P. vivax during pregnancy in very diverse geographical settings. © 2016 Public Library of Science. All rights reserved.
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Authors & Co-Authors
Requena, Pilar
Spain, Barcelona
Instituto de Salud Global de Barcelona
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Padilla, Norma R.
Guatemala, Guatemala City
Universidad Del Valle de Guatemala
Martínez-Espinosa, Flor Ernestina
Brazil, Manaus
Fundacao de Medicina Tropical do Amazonas
Brazil, Manaus
Fiocruz Amazônia
Castellanos, María Eugenia
Guatemala, Guatemala City
Universidad Del Valle de Guatemala
Boˆtto-Menezes, Camila Helena Aguiar
Brazil, Manaus
Fundacao de Medicina Tropical do Amazonas
Brazil, Manaus
Universidade do Estado do Amazonas
Arev́alo-Herrera, Myriam
Colombia, Cali
Universidad Del Valle, Cali
Kochar, Swati
India, Mysore
Mysore Medical College
Kochar, Sanjay Kumar
India, Mysore
Mysore Medical College
Kochar, Dhanpat Kumar
India, Mysore
Mysore Medical College
Umbers, Alexandra J.
Australia, Melbourne
University of Melbourne
Ome-Kaius, Maria
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Wangnapi, Regina Alice
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Menegon, Michela
Italy, Rome
Istituto Superiore Di Sanita
Sanz, Sergi M.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Desai, Meghna R.
United States, Atlanta
Centers for Disease Control and Prevention
Mayor, A. G.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Chitnis, Chetan E.
India, New Delhi
International Centre for Genetic Engineering and Biotechnology, new Delhi
Bardají, Azucena
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mueller, Ivo
Spain, Barcelona
Instituto de Salud Global de Barcelona
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Rogerson, Stephen J.
Australia, Melbourne
University of Melbourne
Severini, Carlo
Italy, Rome
Istituto Superiore Di Sanita
Fernandez-Becerra, C.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Menéndez, Clara
Spain, Barcelona
Instituto de Salud Global de Barcelona
Del Portillo, Hernando A.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Dobaño, Carlota
Spain, Barcelona
Instituto de Salud Global de Barcelona
Statistics
Citations: 15
Authors: 25
Affiliations: 16
Identifiers
Doi:
10.1371/journal.pntd.0005009
ISSN:
19352727
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Guinea
Participants Gender
Female