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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Inhibition of Ras-GTPase signaling by FPTIII ameliorates development of cardiovascular dysfunction in diabetic-hypertensive rats
Vascular Pharmacology, Volume 49, No. 4-6, Year 2008
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Description
We studied the effect an inhibitor of Ras-GTPase (FPTIII, 1.5 mg/kg alt diem for 4 weeks) on mean arterial pressure (MAP), urine protein, vascular reactivity and cardiac function in streptozotocin (STZ)-induced diabetes in control normotensive (WKY) and spontaneously hypertensive rats (SHR). The increased urinary protein in STZ-treated WKY (D-WKY) and STZ-treated SHR (D-SHR) were significantly lower in FPTIII treated D-WKY and D-SHR. The abnormal vascular responsiveness to endothelin-1, angiotensin II, carbachol or histamine in isolated carotid artery from D-WKY and D-SHR was improved by chronic treatment with FPTIII. In isolated perfused hearts, recovery of left ventricular function from 40 min of global ischemia was significantly improved in FPTIII treated D-WKY and D-SHR. These results show that treatment with FPTIII can attenuate development of abnormal vascular reactivity and renal/cardiac dysfunction during simultaneous occurrence of hypertension and diabetes. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Yousif, Mariam H.M.
Kuwait, Kuwait City
Kuwait University
Benter, Ibrahim Fadil
Kuwait, Kuwait City
Kuwait University
Abul, Ahmed H.T.
Kuwait, Kuwait City
Kuwait University
Abraham, Saju
Kuwait, Kuwait City
Kuwait University
Walther, Thomas
Germany, Berlin
Charité – Universitätsmedizin Berlin
Akhtar, Saghir
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 8
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.vph.2008.05.004
ISSN:
15371891
Research Areas
Noncommunicable Diseases