Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry
Cancer Epidemiology Biomarkers and Prevention, Volume 21, No. 3, Year 2012
Notification
URL copied to clipboard!
Description
Background: Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight. Methods: We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies. Results: We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk. Conclusion: The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist. Impact: The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk. ©2012 AACR.
Authors & Co-Authors
Hou, Ningqi
United States, Chicago
The University of Chicago
Zheng, Yonglan
United States, Chicago
The University of Chicago
Gamazon, Eric R.
United States, Chicago
The University of Chicago
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University of Ibadan
Adebamowo, Clement
United States, Baltimore
University of Maryland, Baltimore Umb
Nathanson, Katherine L.
United States, Philadelphia
University of Pennsylvania
Domchek, Susan M.
United States, Philadelphia
University of Pennsylvania
Rebbeck, Timothy R.
United States, Philadelphia
University of Pennsylvania
Simon, Michael S.
United States, Detroit
Wayne State University
John, Esther M.
United States, Stanford
Stanford Cancer Institute
Hennis, Anselm J.M.
Jamaica, Kingston
The University of the West Indies
Nemesure, Barbara Berger
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Wu, Suhyuh
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Leske, Maria Cristina
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Ambs, Stefan
United States, Rockville
National Cancer Institute Nci
Niu, Qun
United States, Chicago
The University of Chicago
Zhang, Jing
United States, Chicago
The University of Chicago
Pierce, Brandon
United States, Chicago
The University of Chicago
Cox, Nancy Jean
United States, Chicago
The University of Chicago
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Huo, Dezheng
United States, Chicago
The University of Chicago
Statistics
Citations: 21
Authors: 21
Affiliations: 9
Identifiers
Doi:
10.1158/1055-9965.EPI-11-0979
ISSN:
10559965
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Participants Gender
Female